DEPOT TESTOSTERONE IN BOYS WITH ANORCHIA OR GONADOTROPIN-DEFICIENCY - EFFECT ON GROWTH-RATE AND ADULT HEIGHT
DEPOT TESTOSTERONE IN BOYS WITH ANORCHIA OR GONADOTROPIN-DEFICIENCY - EFFECT ON GROWTH-RATE AND ADULT HEIGHT
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DOI：
10.1136/adc.66.2.197
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发表时间：
1991-02-01
影响因子：
5.2
通讯作者：
GRANT, DB
中科院分区：
文献类型：
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作者：
MOORTHY, B;PAPADOPOLOU, M;GRANT, DB
11名患有双侧厌食症的青少年男孩和12名患有促性腺激素缺乏症的青少年男孩通过注射睾酮酯（庚酸酯）进行治疗，初始剂量为每6至8周100 mg，3至4年后每四周增加到250 mg。 在正常男孩中，平均成年身高为177.1 cm，而平均父母身高为174.4 cm，平均预测成年身高为177.0 cm（Tanner-Whitehouse方法）和178.0 cm（Bayley-Pinneau方法）。 在促性腺激素缺乏症患者中，平均成人身高为176.9 cm，而平均父母身高中位数为176.1 cm，平均预测成人身高为174.0 cm（Tanner-Whitehouse法）和177.3 cm（Bayley-Pinneau法）。 我们的结论是，这种睾酮方案允许实现充分的增长潜力，在这样的患者。
Eleven teenage boys with bilateral anorchia and 12 with gonadotrophin deficiency were treated by injections of testosterone ester (enanthate) at an initial dose of 100 mg every six to eight weeks, rising to 250 mg every four weeks after three to four years. In the anorchic boys average adult height was 177.1 cm, compared with a mean mid-parental height of 174.4 cm, and mean predicted adult heights of 177.0 cm (Tanner-Whitehouse method) and 178.0 cm (Bayley-Pinneau method). In the patients with gonadotrophin deficiency, mean adult height was 176.9 cm, compared with a mean mid-parental height of 176.1 cm, and mean predicted adults heights of 174.0 cm (Tanner-Whitehouse method) and 177.3 cm (Bayley-Pinneau method). We conclude that this testosterone regimen allows achievement of full growth potential in such patients.