Immunobiotics for the Bovine Host: Their Interaction with Intestinal Epithelial Cells and Their Effect on Antiviral Immunity.
Immunobiotics for the Bovine Host: Their Interaction with Intestinal Epithelial Cells and Their Effect on Antiviral Immunity.
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DOI：
10.3389/fimmu.2018.00326
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发表时间：
2018
影响因子：
7.3
通讯作者：
Kitazawa H
中科院分区：
文献类型：
--
作者：
Villena J;Aso H;Rutten VPMG;Takahashi H;van Eden W;Kitazawa H
科学界已经报告了几起微生物在地球不同地区表现出高抗药性的案例。由于抗菌素耐药微生物的出现，世界上大多数国家都禁止使用抗生素作为家畜生长的促进剂。因此，农业免疫学的挑战之一是通过在不依赖药物的安全食品生产系统中调节动物的免疫系统来寻找替代方案。在这方面，为了努力取代牛饲料中的抗生素，提出了几种替代品，包括使用免疫调节性益生菌(免疫生物素)。本文综述了免疫生物制剂对牛肠道抗病毒天然免疫的调节作用，以及免疫生物制剂对病毒感染的有益影响，主要集中在肠道上皮细胞(IECS)。我们小组的结果表明，免疫生物菌株能够有益地调节牛IECS中Toll样受体3触发的免疫反应，并提高对病毒感染的抵抗力。本综述提供了牛IECS对病毒的先天免疫应答的全面信息，可为进一步研究旨在提高牛宿主防御能力的策略提供参考。
The scientific community has reported several cases of microbes that exhibit elevated rates of antibiotic resistance in different regions of the planet. Due to this emergence of antimicrobial resistant microorganisms, the use of antibiotics as promoters of livestock animals’ growth is being banned in most countries around the world. One of the challenges of agricultural immunology therefore is to find alternatives by modulating the immune system of animals in drug-independent safe food production systems. In this regard, in an effort to supplant antibiotics from bovine feeds, several alternatives were proposed including the use of immunomodulatory probiotics (immunobiotics). The purpose of this review is to provide an update of the status of the modulation of intestinal antiviral innate immunity of the bovine host by immunobiotics, and the beneficial impact of immunobiotics on viral infections, focused on intestinal epithelial cells (IECs). The results of our group, which demonstrate the capacity of immunobiotic strains to beneficially modulate Toll-like receptor 3-triggered immune responses in bovine IECs and improve the resistance to viral infections, are highlighted. This review provides comprehensive information on the innate immune response of bovine IECs against virus, which can be further investigated for the development of strategies aimed to improve defenses in the bovine host.