Parabrachial internal lateral neurons convey nociceptive messages from the deep laminas of the dorsal horn to the intralaminar thalamus
Parabrachial internal lateral neurons convey nociceptive messages from the deep laminas of the dorsal horn to the intralaminar thalamus
复制标题
DOI：
10.1523/jneurosci.21-06-02159.2001
复制
发表时间：
2001-03-15
影响因子：
5.3
通讯作者：
Bernard, JF
中科院分区：
文献类型：
--
作者：
Bourgeais, L;Monconduit, L;Bernard, JF
本研究利用反激激活和单单元记录技术，研究了麻醉大鼠臂旁内外侧（PBil）神经元投射到丘脑旁中央核（PC）的生理特性。我们在这里报道，这些神经元中的大多数只对大感受野的伤害性刺激作出反应，并持续放电，这种放电通常比刺激持续时间长几分钟。静脉注射吗啡可抑制这些反应。我们的研究结果证明了一种新的脊髓- pbil -PC通路，它将伤害性信息传递到PC核，然后再投射到前额叶皮层。近年来的临床影像学研究表明，前额叶皮层在疼痛情绪反应中起着重要的作用。这种脊髓- pbil - pc通路可能解释了伤害性信息如何到达前额叶皮层，从而引发难以忍受的厌恶性疼痛。
This study investigates the physiological properties of parabrachial internal lateral (PBil) neurons that project to the paracentral thalamic (PC) nucleus using antidromic activation and single-unit recording techniques in anesthetized rat. We reported here that most of these neurons responded exclusively to the nociceptive stimulation of large receptive fields with a sustained firing that often outlasted the stimulus up to several minutes. These responses were depressed by intravenous morphine.Our results demonstrated a novel spino-PBil-PC pathway, which transmits nociceptive messages to the PC nucleus, which in turn projects to the prefrontal cortex. Recent clinical imaging studies showed the important participation of prefrontal cortex in emotional response to pain. This spino-PBil-PC pathway may explain how nociceptive messages reach the prefrontal cortex and thus trigger unbearable aversive aspects of pain.