Circadian Rhythms and Hormonal Homeostasis: Pathophysiological Implications.
Circadian Rhythms and Hormonal Homeostasis: Pathophysiological Implications.
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DOI：
10.3390/biology6010010
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发表时间：
2017-02-04
期刊：
影响因子：
4.2
通讯作者：
Bruscalupi G
中科院分区：
文献类型：
--
作者：
Gnocchi D;Bruscalupi G
近年来，人们对控制生物钟和昼夜节律的分子机制有了更深入的理解。事实上，许多研究都有助于揭示分子时钟对调节我们生理机能的重要性，包括激素和代谢稳态。在这里，我们将审查的结构，组织和分子机制，使我们的生物钟的工作，其相关性的正常运作的生理过程。我们还将描述昼夜节律和内分泌稳态之间的相互联系，以及昼夜节律失调可能在几种病理性疾病的发展中产生的潜在后果。最后，我们将讨论如何更好地了解这种关系可能有助于设计新的治疗方法，内分泌和代谢疾病。
Over recent years, a deeper comprehension of the molecular mechanisms that control biological clocks and circadian rhythms has been achieved. In fact, many studies have contributed to unravelling the importance of the molecular clock for the regulation of our physiology, including hormonal and metabolic homeostasis. Here we will review the structure, organisation and molecular machinery that make our circadian clock work, and its relevance for the proper functioning of physiological processes. We will also describe the interconnections between circadian rhythms and endocrine homeostasis, as well as the underlying consequences that circadian dysregulations might have in the development of several pathologic affections. Finally, we will discuss how a better knowledge of such relationships might prove helpful in designing new therapeutic approaches for endocrine and metabolic diseases.