RANTES gene polymorphism in polymyalgia rheumatica, giant cell arteritis and rheumatoid arthritis.
RANTES gene polymorphism in polymyalgia rheumatica, giant cell arteritis and rheumatoid arthritis.
复制标题
风湿性多肌痛、巨细胞动脉炎和类风湿性关节炎中的 RANTES 基因多态性。
DOI：
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发表时间：
2000
影响因子：
3.7
通讯作者：
A. Hajeer
中科院分区：
文献类型：
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作者：
R. Makki;F. Sharif;M. Gonzalez;C. García‐Porrúa;W. Ollier;A. Hajeer
目的
研究RANTES基因启动子区（403位）双等位基因多态性（A或G）是否与风湿性多肌痛（PMR）、巨细胞动脉炎（GCA）和类风湿性关节炎（RA）相关。
方法
采用PCR-RFLP方法对病例和对照进行基因分型。检查了3组患者;这些患者包括未表现出PMR特征的GCA患者（n = 30）、未表现出GCA特征的PMR患者（n = 53）和RA患者（n = 99）。所有患者和对照组（n = 65）均来自西班牙西北部加利西亚卢戈周围地区。
结果
PMR患者A等位基因频率显著高于正常对照组。在类风湿性关节炎患者中观察到该等位基因频率略有增加，但在GCA患者中未观察到。
结论
这是第一个报告的关联RANTES基因多态性与PMR和RA。我们的数据表明RANTES在PMR和RA的发展中可能发挥作用。
OBJECTIVE
To investigate whether a biallelic polymorphism (A or G) occurring within the promoter region of the RANTES gene (position-403) is associated with polymyalgia rheumatica (PMR), giant cell arteritis (GCA) and rheumatoid arthritis (RA).
METHODS
A PCR-RFLP method was used to genotype cases and controls for this polymorphism. 3 groups of patients were examined; these comprised GCA patients who did not exhibit features of PMR (n = 30), PMR patients who did not exhibit features of GCA (n = 53) and RA patients (n = 99). All patients and controls (n = 65) originated from the area surrounding Lugo, Galicia, NW Spain.
RESULTS
A significant increase in the frequency of allele A was found in PMR patients compared with normal controls. A marginal increase of this allele frequency was observed in RA but not in GCA patients.
CONCLUSION
This is the first report of an association of a RANTES gene polymorphisms with PMR and RA. Our data suggest a possible role for of RANTES in the development of both PMR and RA.