Prognostic value of ALDH1 expression in lung cancer: a meta-analysis.
Prognostic value of ALDH1 expression in lung cancer: a meta-analysis.
复制标题
DOI：
--
复制
发表时间：
2015-02
影响因子：
0.1
通讯作者：
W. Huo;M. Du;Xinyan Pan;Xiao-min Zhu;Zhi-min Li
中科院分区：
文献类型：
--
作者：
W. Huo;M. Du;Xinyan Pan;Xiao-min Zhu;Zhi-min Li
目的ALDH1最近被报道为肺癌中癌症干细胞样细胞的标志物。然而，ALDH1对肺癌的预测价值仍存在争议。在这项研究中，我们旨在通过荟萃分析来评估ALDH1表达与肺癌患者临床病理特征和预后的关系。方法：选取截至2014年10月评估ALDH1在肺癌中的临床或预后意义的出版物。进行荟萃分析以阐明ALDH1表达与临床结果之间的关系。结果纳入10篇符合标准的出版物，共1836例患者。这些数据的分析显示，ALDH1表达与淋巴结转移（合并OR = 1.45, 95% CI: 1.04-2.02, P = 0.027）、总生存率降低（合并RR: 2.25, 95% CI: 1.15-4.41, P = 0.019）和无病生存率降低（合并RR: 1.63, 95% CI: 1.01-2.64, P = 0.047）高度相关。结论aldh1阳性肺癌患者预后较差，与常见的临床病理不良因素有关。
OBJECTIVE ALDH1 has recently been reported as a marker of cancer stem-like cells in lung cancer. However, the predictive value of ALDH1 in lung cancer remains controversial. In this study, we aimed to evaluate the association of ALDH1 expression with the clinicopathological features and outcomes of lung cancer patients through a meta-analysis. METHODS Publications that assessed the clinical or prognostic significance of ALDH1 in lung cancer up to October 2014 were identified. A meta-analysis was performed to clarify the association between ALDH1 expression and clinical outcomes. RESULTS Ten eligible publications with 1836 patients were included. The analysis of these data showed that ALDH1 expression was highly correlated with lymph node metastasis (pooled OR = 1.45, 95% CI: 1.04-2.02, P = 0.027), decreased overall survival (pooled RR: 2.25, 95% CI: 1.15-4.41, P = 0.019), and decreased disease-free survival (pooled RR: 1.63, 95% CI: 1.01-2.64, P = 0.047). CONCLUSION Patients with ALDH1-positive lung cancer had poor prognosis, which was associated with common clinicopathological poor prognostic factors.