Emergent mechanical properties of self-assembled polymeric capsules
Emergent mechanical properties of self-assembled polymeric capsules
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DOI：
10.1073/pnas.97.23.12418
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发表时间：
2000-11-07
影响因子：
11.1
通讯作者：
Rebek, J
中科院分区：
文献类型：
--
作者：
Castellano, RK;Clark, R;Rebek, J
合成自组装系统将响应性和可逆性与执行分子识别和催化等化学任务的能力结合起来。一个尚未解决的挑战是构建像自然界的微管蛋白一样的聚合物材料。同时是可逆的并且能够完成有用的体力任务。我们在这里报告了一类可逆形成的聚合物，它们在溶液和固态下表现出共价聚合物的机械完整性。非牛顿。尽管各个亚基的分子量较低且将组件结合在一起的力看似较弱，但仍观察到聚合行为。这些聚合物通过自互补氢键和小分子的物理封装进行组装；因此，新出现的宏观结构和功能可以通过适当的化学信号来控制。
Synthetic self-assembled systems combine responsiveness and reversibility with the ability to perform chemical tasks such as molecular recognition and catalysis. An unmet challenge is the construction of polymeric materials that, like nature's tubulin. are simultaneously reversible and capable of useful physical tasks. We report here a class of reversibly formed polymers that show covalent-polymer mechanical integrity in solution and in the solid state. Non-Newtonian. polymeric behavior is observed despite the low molecular weight of the individual subunits and the seemingly weak forces holding the assemblies together. These polymers assemble through self-complementary hydrogen bonding and by physical encapsulation of small molecules; accordingly, the emergent macroscopic structure and function can be controlled by appropriate chemical signals.