Impact of blood glucose, diabetes, insulin, and obesity on standardized uptake values in tumors and healthy organs on 18F-FDG PET/CT
Impact of blood glucose, diabetes, insulin, and obesity on standardized uptake values in tumors and healthy organs on 18F-FDG PET/CT
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DOI：
10.1016/j.nucmedbio.2012.10.014
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发表时间：
2013-02-01
影响因子：
3.1
通讯作者：
Wasser, Klaus
中科院分区：
文献类型：
--
作者：
Buesing, Karen A.;Schoenberg, Stefan O.;Wasser, Klaus
简介：慢性葡萄糖代谢改变会干扰恶性组织和健康器官中的F-18-FDG摄取，因此可能会降低F-18-FDG PET/CT中的肿瘤检出率。本研究评估了血糖水平升高（BGL），糖尿病，胰岛素治疗和肥胖对F-18-FDG摄取肿瘤和生物分布在正常器官tissues.Methods：F-18-FDG PET/CT的影响进行了分析，在90例BGL范围从50至372 mg/dl。其中，29名患者患有糖尿病，21名患者在PET/CT之前接受了胰岛素治疗; 28名患者肥胖，体重指数>25。测量正常器官和主要肿瘤部位的最大标准摄取值（SUVmax）。比较和不升高BGL，糖尿病，胰岛素治疗和肥胖患者的SUVmax的差异，并分析统计学意义。结果：BGL增加与脑FOG摄取减少和骨骼肌摄取增加。糖尿病和胰岛素减少了这种影响，而肥胖则略微增强了这种结果。糖尿病和胰岛素也增加了肌肉细胞和脂肪的平均SUVmax，而平均大脑SUVmax降低。肥胖使几个健康器官的示踪剂摄取减少了30%。BGL，糖尿病，胰岛素，或obesity.Conclusions：BGL，糖尿病，胰岛素和肥胖的变化影响FOG在肌肉组织和大脑中的生物分布，肿瘤摄取没有显着影响。虽然肿瘤摄取没有明显受损，但这些发现可能会影响肿瘤检出率，因此对于恶性疾病的诊断和随访至关重要。(C)2013 Elsevier Inc. All rights reserved.
Introduction: Chronically altered glucose metabolism interferes with F-18-FDG uptake in malignant tissue and healthy organs and may therefore lower tumor detection in F-18-FDG PET/CT. The present study assesses the impact of elevated blood glucose levels (BGL), diabetes, insulin treatment, and obesity on F-18-FDG uptake in tumors and biodistribution in normal organ tissues.Methods: F-18-FDG PET/CT was analyzed in 90 patients with BGL ranging from 50 to 372 mg/dl. Of those, 29 patients were diabetic and 21 patients had received insulin prior to PET/CT; 28 patients were obese with a body mass index >25. The maximum standardized uptake value (SUVmax) of normal organs and the main tumor site was measured. Differences in SUVmax in patients with and without elevated BGLs, diabetes, insulin treatment, and obesity were compared and analyzed for statistical significance.Results: Increased BGLs were associated with decreased cerebral FOG uptake and increased uptake in skeletal muscle. Diabetes and insulin diminished this effect, whereas obesity slightly enhanced the outcome. Diabetes and insulin also increased the average SUVmax in muscle cells and fat, whereas the mean cerebral SUVmax was reduced. Obesity decreased tracer uptake in several healthy organs by up to 30%. Tumoral uptake was not significantly influenced by BGL, diabetes, insulin, or obesity.Conclusions: Changes in BGLs, diabetes, insulin, and obesity affect the FOG biodistribution in muscular tissue and the brain. Although tumoral uptake is not significantly impaired, these findings may influence the tumor detection rate and are therefore essential for diagnosis and follow-up of malignant diseases. (C) 2013 Elsevier Inc. All rights reserved.