Optimization of the method for assessment of brain perfusion in humans using contrast-enhanced reflectometry: multidistance time-resolved measurements
Optimization of the method for assessment of brain perfusion in humans using contrast-enhanced reflectometry: multidistance time-resolved measurements
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DOI：
10.1117/1.jbo.20.10.106013
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发表时间：
2015-10-01
影响因子：
3.5
通讯作者：
Liebert, Adam
中科院分区：
文献类型：
--
作者：
Milej, Daniel;Janusek, Dariusz;Liebert, Adam
本研究的目的是确定在近红外波长范围内使用光学造影剂和时间分辨漫反射仪评估脑灌注的最佳测量条件。在源探测器分离时，光子的飞行时间（DTOF）分布提供了造影剂流入脑内脑组织腔室的有用信息。进行了一系列蒙特卡罗模拟，模拟了染料在脑外和脑内组织腔室的流入和冲洗，并获得了不同源检测器分离下的dtof。此外，漫射幻影的测试使用时间分辨装置进行，允许在16源-检测器分离处测量dof。最后，将该装置应用于成人志愿者静脉注射吲哚菁绿时的头部实验。对实测DTOFs的统计矩分析表明，连续波反射法监测脑内脑组织腔室的光学对比流入时，推荐源检测器距离为6 cm，而当DTOFs具有高阶矩时，距离为4 cm就足够了。（三）2015年中国光学仪器工程师学会
The aim of the study was to determine optimal measurement conditions for assessment of brain perfusion with the use of optical contrast agent and time-resolved diffuse reflectometry in the near-infrared wavelength range. The source-detector separation at which the distribution of time of flights (DTOF) of photons provided useful information on the inflow of the contrast agent to the intracerebral brain tissue compartments was determined. Series of Monte Carlo simulations was performed in which the inflow and washout of the dye in extra-and intracerebral tissue compartments was modeled and the DTOFs were obtained at different source-detector separations. Furthermore, tests on diffuse phantoms were carried out using a time-resolved setup allowing the measurement of DTOFs at 16 source-detector separations. Finally, the setup was applied in experiments carried out on the heads of adult volunteers during intravenous injection of indocyanine green. Analysis of statistical moments of the measured DTOFs showed that the source-detector separation of 6 cm is recommended for monitoring of inflow of optical contrast to the intracerebral brain tissue compartments with the use of continuous wave reflectometry, whereas the separation of 4 cm is enough when the higher-order moments of DTOFs are available. (C) 2015 Society of Photo-Optical Instrumentation Engineers (SPIE)