Understanding replication fork progression, stability, and chromosome fragility by exploiting the Suppressor of Underreplication protein.
Understanding replication fork progression, stability, and chromosome fragility by exploiting the Suppressor of Underreplication protein.
复制标题
通过利用复制不足抑制蛋白来了解复制叉的进展、稳定性和染色体脆弱性。
DOI：
10.1002/bies.201500021
复制
发表时间：
2015
期刊：
影响因子：
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通讯作者：
Orr-Weaver,TerryL
中科院分区：
文献类型：
--
作者：
Nordman,JaredT;Orr-Weaver,TerryL
There are many layers of regulation governing DNA replication to ensure that genetic information is accurately transmitted from mother cell to daughter cell. While much of the control occurs at the level of origin selection and firing, less is known about how replication fork progression is controlled throughout the genome. InDrosophilapolytene cells, specific regions of the genome become repressed for DNA replication, resulting in underreplication and decreased copy number. Importantly, underreplicated domains share properties with common fragile sites. The Suppressor of Underreplication protein SUUR is essential for this repression. Recent work established that SUUR functions by directly inhibiting replication fork progression, raising several interesting questions as to how replication fork progression and stability can be modulated within targeted regions of the genome. Here we discuss potential mechanisms by which replication fork inhibition can be achieved and the consequences this has on genome stability and copy number control.
