LONG-TERM OBSERVATION OF IN-VIVO P-31 NMR-SPECTRA IN CARBON TETRACHLORIDE-INTOXICATED RABBIT LIVER USING IMPLANTED WIRELESS SURFACE COIL
LONG-TERM OBSERVATION OF IN-VIVO P-31 NMR-SPECTRA IN CARBON TETRACHLORIDE-INTOXICATED RABBIT LIVER USING IMPLANTED WIRELESS SURFACE COIL
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DOI：
10.1002/nbm.1940080103
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发表时间：
1995-02-01
影响因子：
2.9
通讯作者：
AMANO, S
中科院分区：
文献类型：
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作者：
MORIKAWA, S;INUBUSHI, T;AMANO, S
在慢性CCl_4中毒模型上，用植入的无线表面线圈连续观察了5个多月的家兔肝脏~（31）P NMR谱。所获得的NMR光谱的质量是令人满意的，并且有足够的时间分辨率来跟踪果糖耐受性测试期间发生的动态变化。植入的弹簧圈未导致任何严重不良反应，如感染或肝功能障碍。在18周的CCl 4给药期间，磷酸二酯峰面积显著降低。P-i/β-ATP比值一过性升高，逐渐恢复至对照水平。在果糖耐受试验中，静脉注射果糖后磷酸单酯含量明显增加，β-ATP和β-ATP含量明显下降，但在CCl_4中毒时，这些变化的程度变小。该无线表面线圈可用于连续和非侵入性的肝脏P-31 NMR观察，以跟踪几个月内长期治疗的动物模型。
Phosphorus-31 NMR spectra in rabbit liver were successively observed for more than 5 months in a chronic CCl4 intoxication model using implanted wireless surface coils. The quality of the obtained NMR spectra was satisfactory and there was sufficient time resolution to follow the dynamic changes that occurred during a fructose tolerance test. The implanted coil did not lead to any serious adverse effects such as infection or liver dysfunction. During an 18-week administration of CCl4, the area of the phosphodiester peak significantly decreased. The ratio of P-i/beta-ATP was transiently elevated and gradually returned to the control level. In the fructose tolerance test, the increase in phosphomonoester and the decrease in P-i and beta-ATP after i.v. fructose loading were apparent, but the degrees in these changes became smaller during the CCl4 intoxication. This wireless surface coil was useful for consecutive and non-invasive P-31 NMR observations of the liver to follow chronically treated animal models over a period of several months.