α2-adrenoceptors in the basal ganglia have a role in memory consolidation and reinforcement
α2-adrenoceptors in the basal ganglia have a role in memory consolidation and reinforcement
复制标题
基底神经节中的α2-肾上腺素受体在记忆巩固和强化中发挥作用
DOI：
10.1016/s0028-3908(03)00172-2
复制
发表时间：
2003
影响因子：
4.7
通讯作者：
R. Summers
中科院分区：
文献类型：
--
作者：
M. Gibbs;R. Summers
本研究采用弱强化和强强化的小鸡辨别性回避学习模型，证明了基底神经节α2肾上腺素受体在记忆巩固中的作用。α_2-肾上腺素受体拮抗剂育亨宾存在时，将去甲肾上腺素注入基底神经节（嗅旁叶-LPO）的记忆增强作用减弱，但当将去甲肾上腺素注入多模式联合区（中间内侧上纹状体腹侧-IMHV）时，育亨宾不能阻止记忆增强作用。将育亨宾注射到LPO中可防止记忆的巩固，而α2肾上腺素受体激动剂羟甲唑啉和可乐定可增强记忆的巩固。育亨宾抑制LPO中α_2-AR的作用时间表明，α_2-AR参与了训练后10-15 min的活动，刺激LPO中的α_2-AR对随后的记忆巩固是必要的。羟甲唑啉是亲水性的，注射到IMHV无效，而亲脂性α2-肾上腺素受体激动剂可乐定在IMHV中的作用被解释为在脑中更远端的部位（可能是LPO）的作用。结果提示，鸡基底节内去甲肾上腺素的释放可刺激α2肾上腺素受体，从而调节和巩固联合区内β2或β3 AR介导的记忆形成。LPO可能负责IMHV中记忆的强化。
This study demonstrates a role for α2-adrenoceptors in the basal ganglia in the consolidation of memory using weakly and strongly reinforced models of discriminated avoidance learning in the chick. The memory enhancing action of noradrenaline injected into the basal ganglia (lobus parolfactorius—LPO) was reduced in the presence of the α2-adrenoceptor antagonist yohimbine, but when noradrenaline was injected into the multi-modal association area (intermediate medial hyperstriatum ventrale—IMHV), yohimbine failed to prevent memory enhancement. Yohimbine injected into the LPO prevented, whereas the α2-adrenoceptor agonists oxymetazoline and clonidine enhanced, consolidation of memory. The timing of the inhibitory effect of yohimbine in the LPO suggested that α2-adrenoceptor involvement occurs 10–15 min after training, and that stimulation of α2-ARs in LPO is necessary for subsequent consolidation of memory. Oxymetazoline, being hydrophilic, was ineffective injected into IMHV, whereas the action of the lipophilic α2-adrenoceptor agonist clonidine in the IMHV was interpreted as an action at a site more distal in the brain, probably the LPO. The results suggest that noradrenaline release in the basal ganglia in the chick stimulates α2-adrenoceptors, which modulate and consolidate memory formation mediated by β2- or β3-ARs in the association area. The LPO may be responsible for the reinforcement of memory in the IMHV.
去甲肾上腺素能对前额皮质认知功能的影响：连接后 α 1 与 α 2 肾上腺素能受体的相反作用。
DOI：
10.1016/s1054-3589(08)60859-5
发表时间：
1998
期刊：
Advances in pharmacology (San Diego, Calif.)
影响因子：
--
作者：
Arnsten,AF;Steere,JC;Jentsch,DJ;Li,BM
通讯作者：
Li,BM