Wine, beer and spirits and risk of oral and pharyngeal cancer: a case-control study from Italy and Switzerland
Wine, beer and spirits and risk of oral and pharyngeal cancer: a case-control study from Italy and Switzerland
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DOI：
10.1016/j.oraloncology.2004.04.005
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发表时间：
2004-10-01
期刊：
影响因子：
4.8
通讯作者：
La Vecchia, C
中科院分区：
文献类型：
--
作者：
Altieri, A;Bosetti, C;La Vecchia, C
我们使用1992年至1997年在意大利和瑞士进行的病例对照研究的数据，研究了不同类型酒精饮料的消费与口腔癌和咽癌风险之间的关系。这包括749例口腔和咽癌病例和1,772例医院对照，这些病例因急性非肿瘤性疾病而入院，与饮酒和吸烟无关。随着总酒精摄入量的增加，发现风险有显著趋势，与戒酒者或轻度饮酒者（每天少于或等于2杯）相比，每天饮酒3-4杯的饮酒者的多变量比值比（OR）为2.1，5-7杯为5.0，8-11杯为12.2，大于或等于12杯为21.1。葡萄酒饮用者的后续消费水平也发现了类似的风险增加。在考虑葡萄酒摄入量后，啤酒饮用者的OR为1.2（1-2杯/天）和2.3（3杯/天以上）。饮酒者的相应值为1.0和1.9。葡萄酒饮用者的风险模式与只喝葡萄酒的人和喝葡萄酒加上啤酒和烈酒的人相似。我们的研究表明，在经常饮用葡萄酒的人群中，葡萄酒本身会大大增加口腔和咽部癌症的风险，并证实每个人群中最流行的酒精饮料往往是风险最高的饮料。(C)2004 Elsevier Ltd.保留所有权利。
We examined the relation between consumption of different types of alcoholic beverages and the risk of oral and pharyngeal cancer, using data from a case-control study conducted in Italy and Switzerland between 1992 and 1997. This included a total of 749 cases of oral and pharyngeal cancer and 1,772 hospital controls, admitted for acute, non-neoplastic conditions, unrelated to alcohol and smoking consumption. Significant trends in risk were found with increasing total alcohol intake, with multivariate odds ratios (OR) of 2.1 for drinkers of 3-4 drinks/ day, as compared to abstainers or light drinkers ( less than or equal to 2 drinks/day), 5.0 for 5-7, 12.2 for 8-11 and 21.1 for greater than or equal to 12 drinks/day. Similar increased risks for subsequent levels of consumption were found for wine drinkers. After allowance for wine intake, the ORs for beer drinkers were 1.2 for 1-2 drinks/day, and 2.3 for greater than or equal to 3 drinks/day. Corresponding values for spirit drinkers were 1.0 and 1.9. Patterns of risk for wine drinkers were similar for wine only drinkers and drinkers of wine, plus beer and spirits. Our study indicates that in populations with frequent wine consumption, wine per se can strongly increase the risk of cancer of the oral cavity and pharynx, and confirms that the most prevalent alcoholic beverage in each population tends to be the one with the highest risk. (C) 2004 Elsevier Ltd. All rights reserved.