Identification of chemokines and growth factors in proliferative diabetic retinopathy vitreous.
Identification of chemokines and growth factors in proliferative diabetic retinopathy vitreous.
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DOI：
10.1155/2014/486386
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发表时间：
2014
影响因子：
--
通讯作者：
Yu M
中科院分区：
文献类型：
--
作者：
Dai Y;Wu Z;Wang F;Zhang Z;Yu M
研究了玻璃体和增殖性糖尿病视网膜病变（PDR）中趋化因子和生长因子水平之间的关系。入组的58例患者（58只眼）需要行睫状体部玻璃体切除术（PPV），有PDR （n = 32，无牵引性视网膜脱离）或无PDR（非PDR）。黄斑裂孔（MH） 16例，视网膜前膜（ERM） 10例。采用多重免疫测定法，从每位患者未稀释的玻璃体样本中测量11种趋化因子和生长因子的水平。在非pdr眼睛中，11种趋化因子和生长因子的水平在MH患者和ERM患者之间是相似的。然而，与非PDR相比，PDR眼睛中所有11种蛋白的水平都明显更高；CCL17、CCL19和tgf - β3明显上调，这些在PDR中尚未被研究过。PDR中CCL4和CCL11水平的显著升高与先前报道的结果相矛盾。根据Spearman非参数检验，VEGF与其他介质之间存在中强相关性。我们的研究结果表明，这些趋化因子和生长因子可能是单独或与抗vegf药物联合用于治疗PDR的靶向治疗研究的候选药物。
Associations were investigated between levels of chemokines and growth factors in the vitreous and proliferative diabetic retinopathy (PDR). Enrolled were 58 patients (58 eyes) requiring pars plana vitrectomy (PPV), with PDR (n = 32, none with traction retinal detachment) or not (non-PDR). In the latter, 16 had macular hole (MH) and 10 had epiretinal membrane (ERM). With a multiplex bead immunoassay, levels of 11 chemokines and growth factors were measured from the undiluted vitreous sample from each patient. In the non-PDR eyes, the levels of the 11 chemokines and growth factors tested were similar between patients with MH and those with ERM. However, the levels of all 11 were significantly higher in the PDR eyes relative to the non-PDR; CCL17, CCL19, and TGFβ3 were markedly upregulated and have not been investigated in PDR previously. The significantly higher levels of CCL4 and CCL11 in PDR contradict the results of previous reports. Based on Spearman's nonparametric test, moderate-to-strong correlations were found between VEGF and other mediators. Our results indicate that these chemokines and growth factors could be candidates for research into targeted therapies applied either singly or in combination with anti-VEGF drugs for the treatment of PDR.
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