Induction of Apoptosis by Cell-Cycle Phase Specific Drugs
Induction of Apoptosis by Cell-Cycle Phase Specific Drugs
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DOI：
10.1007/978-1-4757-9217-1_14
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发表时间：
1994
期刊：
影响因子：
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通讯作者：
S. Sherwood;R. Schimke
中科院分区：
文献类型：
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作者：
S. Sherwood;R. Schimke
细胞凋亡事件代表了定义死亡细胞的共同生理途径的过程的结果，并且该途径的输入是复杂且高度变化的1 -5。很明显，哺乳动物细胞中细胞毒性剂的作用经常进入细胞凋亡途径，并且已经显示出极其广泛的试剂/治疗在培养的哺乳动物细胞中诱导细胞凋亡事件6，7。然而，重要的是要注意，细胞对特定细胞毒性剂的反应差异很大，并且给定药剂对细胞凋亡的诱导可以在细胞系之间变化。
The events of apoptosis represent the outcome of processes defining a common physiological pathway of dying cells, and the inputs to this pathway are complex and highly varied1–5. It is clear that the actions of cytotoxic agents in mammalian cells frequently feed into the apoptosis pathway, and an extremely wide variety of agents/treatments have been shown to induce the events of apoptosis in cultured mammalian cells6,7. It is important to note, however, that cells vary widely in responses to specific cytotoxic agents and the induction of apoptosis by a given agent can vary between cell lines.