HYPERCALCEMIA IN MALIGNANT LYMPHOMA AND LEUKEMIA
HYPERCALCEMIA IN MALIGNANT LYMPHOMA AND LEUKEMIA
复制标题
恶性淋巴瘤和白血病中的高钙血症
DOI：
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发表时间：
1974
影响因子：
5.2
通讯作者：
G. Canellos
中科院分区：
文献类型：
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作者：
G. Canellos
高钙血症是恶性淋巴瘤和白血病自然史中罕见的并发症。尽管骨和骨髓受累的发生率很高，但与多发性骨髓瘤中这些并发症的相对高发生率形成鲜明对比。值得注意的是，高钙血症的发生是恶性淋巴瘤的一个表现。本报告分析了在一家机构接受评估的大量未经治疗的晚期淋巴瘤患者中高钙血症的发生率和病程及其与初始分期时骨受累的相关性。转移性扩散的模式与骨受累的偏好似乎是更常见的某些组织学亚型的非霍奇金淋巴瘤。此外，考虑到高钙血症的白血病是包括与审查的文献日期。肿瘤导向治疗对控制白血病和淋巴瘤高钙血症的作用的重要性将被考虑。
Hypercalcemia is an uncommon complication of the natural history of malignant lymphoma and leukemia. Despite a high incidence of osseous and marrow involvement, it exists in striking contrast to the relatively high incidence of these complications in multiple myeloma. Of interest is the occurrence of hypercalcemia as a presenting sign of malignant lymphoma. This report is an analysis of the incidence and course of hypercalcemia and its correlation with osseous involvement at the time of initial staging in a large number of untreated patients with advanced lymphoma who were evaluated at a single institution. The patterns of metastatic spread with predilection for bone involvement appear to be more frequent with certain histologic subtypes of the non-Hodgkin’s lymphomas. In addition, a consideration of hypercalcemia in leukemia is included with a review of the literature to date. The importance of the role of tumor-directed therapy on the control of hypercalcemia of leukemia and lymphomas will be considered.