Pattern formation and the mechanics of a motor-driven filamentous system confined by rigid membranes
Pattern formation and the mechanics of a motor-driven filamentous system confined by rigid membranes
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DOI：
10.1103/physrevresearch.4.043071
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发表时间：
2022-10-31
影响因子：
4.2
通讯作者：
Shibata，Tatsuo
中科院分区：
文献类型：
--
作者：
Tarama，Mitsusuke;Shibata，Tatsuo
研究了由刚性膜限制的肌动蛋白丝和肌球蛋白马达的混合物的图案形成和力学。通过使用粗粒度分子动力学模型，我们证明了电机的消耗力和主动力之间的竞争导致了肌动蛋白在膜附近的积累。由此产生的肌动球蛋白结构对膜施加压力，由于细丝的向列排列，压力会收敛到一个常数以获得大的运动主动力。结果与细丝长度和膜曲率无关，表明这种现象的普遍性。因此，本文提出了一种细胞骨架化合物可以自组织成更高阶结构的机制。
Pattern formation and the mechanics of a mixture of actin filaments and myosin motors that is confined by a rigid membrane is investigated. By using a coarse-grained molecular dynamics model, we demonstrate that the competition between the depletion force and the active force of the motors gives rise to actin accumulation in the membrane vicinity. The resulting actomyosin structure exerts pressure on the membrane that, due to nematic alignment of the filaments, converges to a constant for large motor active force. The results are independent of filament length and membrane curvature, indicating the universality of this phenomenon. Thus, this paper proposes a mechanism by which the compounds of the cytoskeleton can self-organize into a higher-order structure.