Predominant Detection of the Subgroup A2b Human Metapneumovirus Strain with a 111-Nucleotide Duplication in the G gene in Yokohama City, Japan in 2018
Predominant Detection of the Subgroup A2b Human Metapneumovirus Strain with a 111-Nucleotide Duplication in the G gene in Yokohama City, Japan in 2018
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DOI：
10.7883/yoken.jjid.2018.124
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发表时间：
2019-09-01
影响因子：
2.2
通讯作者：
Okubo, Ichiro
中科院分区：
文献类型：
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作者：
Saikusa, Miwako;Nao, Naganori;Okubo, Ichiro
人偏肺病毒（HMPV）是人类急性呼吸道感染的主要病原体。最近，在日本、西班牙、越南和中国检测到两种类型的变异A2 b亚型HMPV毒株，它们在G基因中具有111或180个核苷酸的重复（nt-dup）（HMPV A2 b（180 nt-dup）和HMPV A2 b（111 nt-dup））。我们对日本横滨市传染源的监测显示，HMPV A2 b（111 nt-dup）毒株于2018年在横滨市成为主要毒株。相比之下，2017年后未检测到经典HMPV A2 b毒株。这些数据表明，111 nt-dup在G基因的传播HMPV的有益作用。
Human metapneumovirus (HMPV) has been a major causative agent of acute respiratory infections in humans. Recently, two types of variant A2b subtype HMPV strains possessing a 111- or 180-nucleotide duplication (nt-dup) in the G gene (HMPV A2b(180nt-dup) and HMPV A2b(111nt-dup), respectively) were detected in Japan, Spain, Vietnam, and China. Our surveillance for infectious agents in Yokohama City, Japan revealed that the HMPV A2b(111nt-dup) strain became predominant in Yokohama City in 2018. In contrast, no classic HMPV A2b strain was detected after 2017. These data indicate a beneficial role of the 111nt-dup in the G gene for the transmission of HMPV.