Cognate CD4+ T cell licensing of dendritic cells in CD8+ T cell immunity
Cognate CD4+ T cell licensing of dendritic cells in CD8+ T cell immunity
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DOI：
10.1038/ni1129
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发表时间：
2004-11-01
影响因子：
30.5
通讯作者：
Belz, GT
中科院分区：
文献类型：
--
作者：
Smith, CM;Wilson, NS;Belz, GT
一些研究表明，CD8(+) T细胞需要CD4(+) T细胞帮助形成记忆。有证据表明，这种帮助可能是抗原独立的，这就挑战了细胞毒性T淋巴细胞（CTL）反应是否需要CD4(+) T细胞“许可”树突状细胞（dc）。我们在这里表明，帮助对于产生针对单纯疱疹病毒1的CTL免疫是必不可少的，并且CD4(+) T细胞以同源的抗原特异性方式介导帮助。我们提供了辅助T细胞DC许可的直接体内证据，并表明许可对于效应和记忆ctl的形成是快速和必要的。在DC不受病原体来源信号许可的情况下，我们的研究结果表明CTL免疫可能严重依赖同源DC许可。
Several studies have indicated that CD8(+) T cells require CD4(+) T cell help for memory formation. Evidence suggests that such help can be antigen independent, challenging whether the 'licensing' of dendritic cells (DCs) by CD4(+) T cells is ever required for cytotoxic T lymphocyte (CTL) responses. We show here that help is essential for the generation of CTL immunity to herpes simplex virus 1 and that CD4(+) T cells mediate help in a cognate, antigen-specific way. We provide direct in vivo evidence for DC licensing by helper T cells and show that licensing is rapid and essential for the formation of effector and memory CTLs. In situations in which DCs are poorly licensed by pathogen-derived signals, our findings suggest that CTL immunity may be heavily dependent on cognate DC licensing.