Monoclonal antibody-resistant mutants selected with a respiratory syncytial virus-neutralizing human antibody Fab fragment (Fab 19) define a unique epitope on the fusion (F) glycoprotein
Monoclonal antibody-resistant mutants selected with a respiratory syncytial virus-neutralizing human antibody Fab fragment (Fab 19) define a unique epitope on the fusion (F) glycoprotein
复制标题
DOI：
10.1006/viro.1998.9462
复制
发表时间：
1998-12-20
期刊：
影响因子：
3.7
通讯作者：
Murphy, BR
中科院分区：
文献类型：
--
作者：
Crowe, JE;Firestone, CY;Murphy, BR
一个被命名为RSV Fab 19的重组人抗体片段能有效地中和呼吸道合胞病毒(RSV)，本文报道了我们的抗体逃逸突变体的序列分析结果，该突变体鉴定了与人或鼠RSV F中和抗体结合至关重要的F糖蛋白氨基酸。(C)1998年学术出版社。
A recombinant human antibody fragment, designated RSV Fab 19, efficiently neutralizes respiratory syncytial virus (RSV), Here we report the results of our sequence analysis of antibody escape mutants that identified F glycoprotein amino acids critical for binding of human or murine RSV F-neutralizing antibodies. (C) 1998 Academic Press.