Roles of STAT3 in leukemia
Roles of STAT3 in leukemia
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STAT3 在白血病中的作用
DOI：
10.3892/ijo.2018.4386
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发表时间：
2018-07-01
影响因子：
5.2
通讯作者：
Li, Xia
中科院分区：
文献类型：
--
作者：
Shi, Yin;Zhang, Zhen;Li, Xia
白血病是一种造血系统恶性肿瘤，在美国和欧盟，发病率平均每年增加0.6%~ 0.7%。中国的发病率约为5.17/10万人，死亡率为3.94/10万人。白血病是影响儿童和35岁以下成人的最常见肿瘤，也是导致青少年死亡的主要疾病之一。信号转导子和转录激活子3（STAT 3）是信号转导和转录激活的重要调节因子，一旦被激活，其磷酸化形式（p-STAT 3）被转移到细胞核内调节靶基因的转录，在细胞增殖、分化、凋亡等生理过程中发挥重要作用。越来越多的研究证实STAT 3的异常激活参与了肿瘤的发生发展。本文从细胞增殖、分化和凋亡等方面综述了STAT 3在白血病发病机制、诊断、治疗和预后中的作用，旨在进一步阐明STAT 3在白血病中的作用，为临床诊断和治疗提供新的靶点和策略。
Leukemia is a type of hematopoietic malignancy, and the incidence rate in the United States and European Union increases by an average of 0.6 to 0.7% annually. The incidence rate in China is approximately 5.17/100,000 individuals, and the mortality rate is 3.94/100,000 individuals. Leukemia is the most common tumor affecting children and adults under 35 years of age, and is one of the major diseases leading to the death of adolescents. Signal transducer and activator of transcription 3 (STAT3) is a vital regulatory factor of signal transduction and transcriptional activation, and once activated, the phosphorylated form of STAT3 (p-STAT3) is transferred into the nucleus to regulate the transcription of target genes, and plays important roles in cell proliferation, differentiation, apoptosis and other physiological processes. An increasing number of studies have confirmed that the abnormal activation of STAT3 is involved in the development of tumors. In this review, the roles of STAT3 in the pathogenesis, diagnosis, treatment and prognosis of leukemia are discussed in the aspects of cell proliferation, differentiation and apoptosis, with the aim to further clarify the roles of STAT3 in leukemia, and shed light into possible novel targets and strategies for clinical diagnosis and treatment.