LONG-TERM EFFECTS OF RADIOTHERAPY ON TASTE AND SALIVARY FUNCTION IN MAN
LONG-TERM EFFECTS OF RADIOTHERAPY ON TASTE AND SALIVARY FUNCTION IN MAN
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DOI：
10.1016/0360-3016(82)90166-3
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发表时间：
1982-01-01
影响因子：
7
通讯作者：
CHENCHARICK, J
中科院分区：
文献类型：
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作者：
MOSSMAN, K;SHATZMAN, A;CHENCHARICK, J
本文观察了13例头颈部肿瘤放疗后1~7年对味觉和唾液功能的远期影响。味觉功能的定量评估使用了标准的强迫选择、用于确定检测和识别阈值的3刺激下降技术和用于确定味觉强度响应性的强制缩放技术。测定唾液流率和蛋白质分泌率，定量评价腮腺功能。在研究的13名患者中，有9名(69%)有可测量的味觉丧失；每个接受放射治疗的患者，包括腮腺，都有可测量的唾液功能障碍。放射治疗头颈部肿瘤的疗程可能会导致味觉和唾液功能的长期变化。治疗5年后导致50%并发症发生率(TD50/5)的最大耐受剂量估计为口干症40-65Gy[灰色]，味觉丧失50-65Gy.因此，在头颈部肿瘤的标准治疗方案中，出于治疗意图，味觉和唾液腺组织经常遭受最大耐受性损伤。
The long-term effects of radiotherapy on taste and salivary function were studied in 13 patients treated by radiation 1-7 yr previously for tumors of the head and neck. Taste function was quantitatively evaluated using a standard forced choice, 3-stimulus-drop technique for the determination of detection and recognition thresholds and a forced-scaling technique for the determination of taste intensity responsiveness. Parotid salivary function was quantitatively evaluated by determination of flow rate and protein secretion rate. Nine of the 13 patients studied (69%) had measurable taste loss; every patient who had radiotherapy including the parotid glands had measurable salivary dysfunction. Curative courses of radiotherapy for tumors of the head and neck may result in long-term changes in taste and salivary function. The maximum tolerance doses resulting in a 50% complication rate 5 yr after treatment (TD 50/5) are estimated to be 40-65 Gy [gray] for xerostomia and 50-65 Gy for taste loss. Therefore, in a standard treatment regimen for tumors of the head and neck, with curative intent, gustatory and salivary gland tissues frequently sustain maximum tolerance injury.