Differences between risk factors among irritable bowel syndrome subtypes in Japanese adults
Differences between risk factors among irritable bowel syndrome subtypes in Japanese adults
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DOI：
10.1111/j.1365-2982.2010.01640.x
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发表时间：
2011-03-01
影响因子：
3.5
通讯作者：
Arakawa, T.
中科院分区：
文献类型：
--
作者：
Kubo, M.;Fujiwara, Y.;Arakawa, T.
肠易激综合征（Irritable bowel syndrome，IBS）是一种常见的胃肠道疾病。不同IBS亚型患者的详细临床特征尚未完全确定。我们的目的是检查IBS及其亚型的患病率和危险因素在Japaneseadult.MethodsWe进行了横断面研究的日本工人谁访问了诊所进行常规健康检查，并要求他们填写一份自我报告的问卷。肠易激综合征及其亚型按罗马III标准定义。关键结果肠易激综合征存在于367（13.5%）的2717个合格的科目; 79 IBS便秘（IBS-C）; 102 IBS腹泻（IBS-D）; 89混合型IBS（IBS-M）;和97未分型IBS（IBS-U）。肠易激综合征与年轻[比值比（OR）= 0.87，95%可信区间（CI）0.80-0.95]、女性显著相关（OR = 1.78，95%CI 1.38-2.29），低体重指数（BMI）（OR = 0.95，95% CI 0.92-0.99）和存在过敏性疾病（OR = 2.19，95% CI 1.40-3.54）。IBS亚型分析显示，IBS-C与年轻、女性有关，IBS-D与年轻、低BMI、饮酒有关，IBS-M与女性、吸烟、过敏性疾病有关，IBS-D与年龄、BMI、饮酒有关，IBS-M与年龄、吸烟、过敏性疾病有关。结论与推论肠易激综合征是一种常见的肠易激综合征，与年轻、女性、低BMI、以及日本成年人中存在过敏性疾病。不同IBS亚型的危险因素之间存在一些差异。
BackgroundIrritable bowel syndrome (IBS) is a common gastrointestinal disease. Detailed clinical characteristics of patients with different IBS subtypes have not been well established. Our aim was to examine the prevalence and risk factors of IBS and its subtypes in Japanese adults.MethodsWe performed a cross-sectional study of Japanese workers who visited a clinic for a routine health check-up and asked them to fill out a self-report questionnaire. Irritable bowel syndrome and its subtypes were defined by ROME III criteria. A logistic regression model was used to identify risk factors.Key ResultsIrritable bowel syndrome was present in 367 (13.5%) of 2717 eligible subjects; 79 had IBS with constipation (IBS-C); 102 had IBS with diarrhea (IBS-D); 89 had mixed IBS (IBS-M); and 97 had unsubtyped IBS (IBS-U). Irritable bowel syndrome was significantly associated with young age [odds ratio (OR) = 0.87, 95% confidence interval (CI) 0.80-0.95], female gender (OR = 1.78, 95% CI 1.38-2.29), low body mass index (BMI) (OR = 0.95, 95% CI 0.92-0.99), and the presence of allergic disease (OR = 2.19, 95% CI 1.40-3.54). Analysis of IBS subtypes revealed that IBS-C was associated with young age and female gender; IBS-D with young age, low BMI, and drinking habit; IBS-M with female gender, smoking habits, and allergic diseases; and IBS-U with age, female gender, and allergic diseases.Conclusions & InferencesIrritable bowel syndrome was common and associated with young age, female gender, low BMI, and presence of allergic diseases in Japanese adults. Several differences were noted between the risk factors among different IBS subtypes.