Noninvasive, Objective, Multimodal Tear Dynamics Evaluation of 5 Over-the-Counter Tear Drops in a Randomized Controlled Trial
Noninvasive, Objective, Multimodal Tear Dynamics Evaluation of 5 Over-the-Counter Tear Drops in a Randomized Controlled Trial
复制标题
DOI：
10.1097/ico.0b013e31821ea667
复制
发表时间：
2012-02-01
期刊：
影响因子：
2.8
通讯作者：
Aquavella, James V.
中科院分区：
文献类型：
--
作者：
Tung, Cynthia I.;Kottaiyan, Ranjini;Aquavella, James V.
目的：评估无创、客观、多模式系统比较4组不同的5种非处方泪液的功效和光学质量的能力。方法：波前传感和光学相干断层扫描（OCT）分别用于客观评估非处方泪液滴眼液[2聚乙二醇（PEG）-400，1羧甲基纤维素（CMC），在一项随机、对照、双盲试验中，对23名缺水性干眼患者给予1份聚乙烯醇/PEG-400（PVA）和1份甘油/聚山梨酯-80（glycerol/polysorbate-80）。结果：滴注后5分钟，2种PEG滴眼液与CMC、PVA和甘油滴眼液相比，视觉质量明显下降（-128.87%，P = 0.001）。与其他组相比，PEG和CMC滴眼液在5分钟时的泪液体积显著增加（+33.2%，P = 0.002;+29.9%，P < 0.001）。5分钟时Schirmer评分小于5 mm的受试者显示PEG滴剂的视觉质量有所改善，而荧光素染色评分为1至2的受试者显示PEG和CMC滴剂均有所改善。一个趋势，增加撕裂半月板的视觉质量下降noted.Conclusions：非侵入性多模态成像有可能客观地评估泪液动力学和人工泪液的疗效。某些人工泪液成分和滴注人工泪液后泪液体积的暂时增加可能导致视觉质量的暂时降低。
Purpose: To assess the ability of a noninvasive, objective, multimodal system to compare the efficacy and optical quality of 4 different groups of 5 over-the-counter tear drops.Methods: Wavefront sensing and optical coherence tomography (OCT) were used to objectively assess visual quality and tear volume, respectively, after the over-the-counter tear drops [2 polyethylene glycol (PEG)-400, 1 carboxymethyl cellulose (CMC), 1 polyvinyl alcohol/PEG-400 (PVA), and 1 glycerine/polysorbate-80] were administered to 23 patients with aqueous-deficient dry eye in a randomized, controlled, double-masked trial. Measurements at each of the 5 visits were taken from both eyes at baseline and 5, 20, and 40 minutes after drop instillation.Results: At 5 minutes after drop instillation, the 2 PEG drops showed significant worsening of visual quality (-128.87%, P = 0.001) compared with CMC, PVA, and glycerine drops. Tear volume was elevated significantly with PEG and CMC drops at 5 minutes (+33.2%, P = 0.002; +29.9%, P < 0.001) compared with the other groups. Subjects with a Schirmer score of less than 5 mm at 5 minutes showed improvement in visual quality with PEG drops, whereas those with a fluorescein staining score of 1 to 2 showed improvement with both PEG and CMC drops. A trend toward decreasing visual quality with increasing tear meniscus was noted.Conclusions: Noninvasive multimodal imaging has the potential to evaluate tear dynamics and the efficacy of artificial tears objectively. Certain artificial tear components and the temporary increase in tear volume after instillation of artificial tears may contribute to transient reduction of visual quality.