ETIOLOGY OF PRETERM PREMATURE RUPTURE OF THE MEMBRANES
ETIOLOGY OF PRETERM PREMATURE RUPTURE OF THE MEMBRANES
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DOI：
10.1097/00003081-198612000-00005
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发表时间：
1986-12-01
影响因子：
1.5
通讯作者：
PUPKIN, MJ
中科院分区：
文献类型：
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作者：
ALGER, LS;PUPKIN, MJ
马里兰州大学医学院巴尔的摩，马里兰州|大多数妊娠，分娩在足月时开始，因为胎膜是完整的。在没有干预的情况下，膜通常保持完整，直到宫颈扩张约8-9 cm。在实验中，引起胎膜破裂所需的压力不仅大于宫腔的基线静息张力，而且通常超过正常分娩产生的压力。胎膜早破（PROM）的临床表现可发生在未分娩、宫颈未扩张、未足月、甚至卧床休息的情况下，这是一个谜，至今尚未完全解释清楚。尽管早产胎膜早破在早产的病因学中起着重要作用，并可在随后的妊娠中复发，但在大多数临床情况下，其原因并不明显。
University of Maryland School of Medicine Baltimore, Maryland|: most pregnancies, labor begins at term lin the presence of intact fetal mem-branes. Without intervention the mem-branes usually remain intact until approximately 8–9 cm of cervical dilatation. The pressure necessary to cause membrane rupture experimentally not only is greater than the baseline resting tone of the intrauterine cavity but also generally exceeds that generated by normal labor. That the clinical entity of premature rupture of the membranes (PROM) can occur in the ab-sence of labor with an undilated cervix, remote from term, even at bed rest is an enigma that remains only imperfectly explained. Although preterm PROM plays a prominent role in the etiology of preterm labor and can recur in subsequent preg-nancies, in most clinical situations its cause is not apparent.