Effect of systemic intermittent administration of human parathyroid hormone (rhPTH[1-34]) on the resistance to reverse torque in rabbit tibiae.
Effect of systemic intermittent administration of human parathyroid hormone (rhPTH[1-34]) on the resistance to reverse torque in rabbit tibiae.
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DOI：
10.1563/1548-1336-34.6.298
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发表时间：
2008-01-01
期刊：
影响因子：
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通讯作者：
Shibli, Jamil Awad
中科院分区：
文献类型：
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作者：
Corsini, Marcelo Soeiro;Faraco, Fatima N;Shibli, Jamil Awad
本研究的目的是评估间歇性施用人甲状旁腺激素 [rhPTH (1-34)] 对放置在兔胫骨中的植入物移除扭矩的影响。二十只雄性新西兰兔接受了植入手术。每只动物的右胫骨近端干骺端植入一个机加工螺钉型植入物（直径 3.75 毫米 x 长度 8 毫米）。然后将兔子分为 2 组：试验组 (n = 10) 每周 3 天在背部皮下注射 6 微克/公斤的 rhPTH (1-34)，对照组 (n = 10) 接受安慰剂。两组均在种植体植入后 28 天和 56 天进行移除扭矩。对照组和测试组在 28 天时的平均移除扭矩值分别为 37.0 +/- 4.36 Ncm 和 47.4 +/- 6.77 Ncm (P < .05)。第 56 天时，对照组的反向扭矩为 45.8 +/- 3.96 Ncm，测试组为 55.8 +/- 2.86 Ncm，表明测试组的移除扭矩显着较高 (P < .05)。这些结果表明，rhPTH (1-34) 的间歇治疗增强了兔胫骨中植入物的移除扭矩。
The aim of this study was to evaluate the effect of intermittent administration of human parathyroid hormone [rhPTH (1-34)] on the removal torque of implants placed in rabbit tibiae. Twenty male New Zealand rabbits were submitted to implant surgery. Each animal received one machined screw-type implant (3.75 mm diameter x 8 mm length) in the proximal metaphysis of the right tibia. The rabbits were then divided into 2 groups: the test group (n = 10) received 6 microg/kg of rhPTH (1-34) subcutaneously in the dorsal region 3 days a week, and the control group (n = 10) received placebo. Removal torque was performed at 28 and 56 days after implant placement for both groups. The mean removal torque values at 28 days were 37.0 +/- 4.36 Ncm and 47.4 +/- 6.77 Ncm for control and test groups respectively (P < .05). At 56 days the reverse torque was 45.8 +/- 3.96 Ncm for the control group and 55.8 +/- 2.86 Ncm for the test group, indicating that the removal torque was significantly higher in the test groups (P < .05). These results demonstrated that intermittent treatment with rhPTH (1-34) enhanced the removal torque of implants in rabbit tibiae.