Point-of-care lung ultrasonography for early identification of mild COVID-19: a prospective cohort of outpatients in a Swiss screening center.
Point-of-care lung ultrasonography for early identification of mild COVID-19: a prospective cohort of outpatients in a Swiss screening center.
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DOI：
10.1136/bmjopen-2021-060181
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发表时间：
2022-06-24
期刊：
影响因子：
2.9
通讯作者：
Boillat-Blanco, Noemie
中科院分区：
文献类型：
--
作者：
Schaad, Simeon;Brahier, Thomas;Hartley, Mary-Anne;Cordonnier, Jean-Baptiste;Bosso, Luca;Espejo, Tanguy;Pantet, Olivier;Hugli, Olivier;Carron, Pierre-Nicolas;Meuwly, Jean-Yves;Boillat-Blanco, Noemie
Early identification of SARS-CoV-2 infection is important to guide quarantine and reduce transmission. This study evaluates the diagnostic performance of lung ultrasound (LUS), an affordable, consumable-free point-of-care tool, for COVID-19 screening. This prospective observational cohort included adults presenting with cough and/or dyspnoea at a SARS-CoV-2 screening centre of Lausanne University Hospital between 31 March and 8 May 2020. Investigators recorded standardised LUS images and videos in 10 lung zones per patient. Two blinded independent experts reviewed LUS recording and classified abnormal findings according to prespecified criteria to investigate their predictive value to diagnose SARS-CoV-2 infection according to PCR on nasopharyngeal swabs (COVID-19 positive vs COVID-19 negative). We finally combined LUS and clinical findings to derive a multivariate logistic regression diagnostic score. Of 134 included patients, 23% (n=30/134) were COVID-19 positive and 77% (n=103/134) were COVID-19 negative; 85%, (n=114/134) cases were previously healthy healthcare workers presenting within 2–5 days of symptom onset (IQR). Abnormal LUS findings were significantly more frequent in COVID-19 positive compared with COVID-19 negative (45% vs 26%, p=0.045) and mostly consisted of focal pathologic B lines. Combining clinical findings in a multivariate logistic regression score had an area under the receiver operating curve of 80.3% to detect COVID-19, and slightly improved to 84.5% with the addition of LUS features. COVID-19-positive patients are significantly more likely to have lung pathology by LUS. However, LUS has an insufficient sensitivity and is not an appropriate screening tool in outpatients. LUS only adds little value to clinical features alone.
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影响因子：
3.8
作者：
Russell FM;Ferre R;Ehrman RR;Noble V;Gargani L;Collins SP;Levy PD;Fabre KL;Eckert GJ;Pang PS
通讯作者：
Pang PS
影响因子：
38.9
作者：
Volpicelli G;Gargani L;Perlini S;Spinelli S;Barbieri G;Lanotte A;Casasola GG;Nogué-Bou R;Lamorte A;Agricola E;Villén T;Deol PS;Nazerian P;Corradi F;Stefanone V;Fraga DN;Navalesi P;Ferre R;Boero E;Martinelli G;Cristoni L;Perani C;Vetrugno L;McDermott C;Miralles-Aguiar F;Secco G;Zattera C;Salinaro F;Grignaschi A;Boccatonda A;Giostra F;Infante MN;Covella M;Ingallina G;Burkert J;Frumento P;Forfori F;Ghiadoni L;on behalf of the International Multicenter Study Group on LUS in COVID-19
通讯作者：
on behalf of the International Multicenter Study Group on LUS in COVID-19
影响因子：
0.3
作者：
Copetti, Roberto;Amore, Giulia;Meduri, Stefano
通讯作者：
Meduri, Stefano
影响因子：
5.4
作者：
Schisterman, EF;Perkins, NJ;Bondell, H
通讯作者：
Bondell, H
影响因子：
5.9
作者：
Vancheri, Sergio Giuseppe;Savietto, Giovanni;Preda, Lorenzo
通讯作者：
Preda, Lorenzo