CD4+ T cell-dependent reduction in hepatitis C virus-specific humoral immune responses after HIV infection.
CD4+ T cell-dependent reduction in hepatitis C virus-specific humoral immune responses after HIV infection.
复制标题
HIV感染后CD4 T细胞依赖性丙型肝炎病毒特异性体液免疫反应的减少。
DOI：
10.1086/511826
复制
发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Cox,AndreaL
中科院分区：
文献类型：
--
作者：
Netski,DaleM;Mosbruger,Tim;Astemborski,Jacquie;Mehta,ShrutiH;Thomas,DavidL;Cox,AndreaL
背景。人类免疫缺陷病毒（HIV）感染对丙型肝炎病毒（HCV）感染的所有阶段都有不利影响，导致病毒持久性增加，HCV病毒血症水平升高，并加速HCV相关肝病的进展。这些疾病相互作用的部分原因可能是B细胞功能受损，而B细胞功能依赖于CD4+T细胞。方法：为了确定HIV感染对B细胞功能的影响，我们比较了29例HCV感染者感染HIV前后的HCV抗体水平和特异性，并评估了这些变化与CD4+T淋巴细胞总数的时间相关性。结果：HIV感染前HCV抗体滴度是所有抗原滴度的预测因子。CD4+T细胞数量的减少与几种抗原抗hcv滴度的降低密切相关。CD4+T细胞计数<500细胞/mm3与较低的HCV抗体终点滴度显著相关。较高的HCV终点滴度与较短的HIV感染年限有关，对于核心抗原，与当前的药物使用有关。hcv特异性抗体的产生受到HIV感染的损害，抗体产生的损失取决于CD4+T细胞的消耗。然而，那些继续积极注射药物的人滴度的下降不太明显。
Background.Human immunodeficiency virus (HIV) infection adversely affects all stages of hepatitis C virus (HCV) infection, leading to increased rates of viral persistence, higher levels of HCV viremia, and accelerated progression of HCV-related liver disease. These disease interactions may result in part from impairment of B cell function, which is CD4+T cell dependent.Methods.To determine the effect of HIV infection on B cell function, we compared HCV antibody levels and specificities in 29 HCV-infected persons before and after they acquired HIV and assessed the temporal correlation of these changes with overall CD4+T lymphocyte counts.Results.The pre-HIV infection HCV antibody titer was a predictor of the subsequent titer for all antigens, and decreasing CD4+T cell numbers was strongly associated with a decrease in anti-HCV titers for several antigens. CD4+T cells counts of <500 cells/mm3were significantly associated with lower HCV antibody end-point titers. Higher HCV end-point titers were associated with fewer years from HIV infection and, for Core antigen, current drug use.Conclusions.HCV-specific antibody production is impaired by HIV infection, and loss of antibody production depends on CD4+T cell depletion. However, the decrease in titers is less significant in those who continue to actively inject drugs.