Multiple stable states in microbial communities explained by the stable marriage problem
Multiple stable states in microbial communities explained by the stable marriage problem
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DOI：
10.1038/s41396-018-0222-x
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发表时间：
2018-12-01
期刊：
影响因子：
11
通讯作者：
Maslov, Sergei
中科院分区：
文献类型：
--
作者：
Goyal, Akshit;Dubinkina, Veronika;Maslov, Sergei
对微生物群落的实验研究通常表明，它们具有多种稳定状态。虽然这些状态中的每一种通常都是有弹性的，但某些扰动，如抗生素，益生菌和饮食变化，会导致向其他状态的过渡。我们能否可靠地预测这种稳定状态，以及直接和控制它们之间的过渡？在这里，我们提出了一个新的概念模型的灵感来自于博弈论和经济学中的稳定婚姻问题，其中微生物群落自然地表现出多个稳定状态，每个状态都具有不同的物种丰度分布。我们的模型的核心成分是微生物在相互竞争的同时一次利用一种营养物质。仅使用两个排名表，一个是微生物的营养偏好，另一个是它们的竞争能力，我们可以确定所有可能的稳定状态，并预测由去除或添加特定营养素或微生物引发的状态间转换。此外，使用一个例子，七个拟杆菌属物种常见的人类肠道利用九种多糖，我们预测，在营养偏好的相互互补，使这些物种以高丰度共存。
Experimental studies of microbial communities routinely reveal that they have multiple stable states. While each of these states is generally resilient, certain perturbations such as antibiotics, probiotics, and diet shifts, result in transitions to other states. Can we reliably both predict such stable states as well as direct and control transitions between them? Here we present a new conceptual model-inspired by the stable marriage problem in game theory and economics-in which microbial communities naturally exhibit multiple stable states, each state with a different species' abundance profile. Our model's core ingredient is that microbes utilize nutrients one at a time while competing with each other. Using only two ranked tables, one with microbes' nutrient preferences and one with their competitive abilities, we can determine all possible stable states as well as predict inter-state transitions, triggered by the removal or addition of a specific nutrient or microbe. Further, using an example of seven Bacteroides species common to the human gut utilizing nine polysaccharides, we predict that mutual complementarity in nutrient preferences enables these species to coexist at high abundances.