Differential induction of polyamine oxidase activity in liver and heart of iron-overloaded rats.
Differential induction of polyamine oxidase activity in liver and heart of iron-overloaded rats.
复制标题
铁超载大鼠肝脏和心脏中多胺氧化酶活性的差异诱导。
DOI：
10.1080/00984109708984024
复制
发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Khan,MF
中科院分区：
文献类型：
--
作者：
Tipnis,UR;He,GY;Khan,MF
The present study was undertaken to investigate the effect of iron dextran treatment on polyamine oxidase (PAO) activity, iron accumulation, and lipid peroxidation in livers and hearts of rats. PAO catalyzes oxidative deamination of polyamines, the cellular aliphatic cations. This reaction produces highly toxic hydrogen peroxide, 3-acetamidopropanal, and precursors of higher polyamines. The rats were given iron dextran daily for 7 d. In iron-dextran-treated rats, a marked increase in the hepatic level of iron was associated with enhanced lipid peroxidation and increased PAO activity. Though iron accumulation and lipid peroxidation in the iron-treated rats increased significantly in the heart, PAO activity remained unchanged. The paraffin sections of livers stained with Perls iron stain showed the presence of iron in macrophages and hepatocytes. The sections of hearts showed iron deposits only in macrophages, while myocytes showed no iron staining. These results show that although iron dextran treatment results in accumulation of iron in both liver and heart, it induces PAO activity only in liver. The significance of increased PAO activity in lipid peroxidation and fibrosis in iron-mediated injury is discussed.
