Murine NK-cell licensing is reflective of donor MHC-I following allogeneic hematopoietic stem cell transplantation in murine cytomegalovirus responses
Murine NK-cell licensing is reflective of donor MHC-I following allogeneic hematopoietic stem cell transplantation in murine cytomegalovirus responses
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DOI：
10.1182/blood-2013-02-483503
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发表时间：
2013-08-22
期刊：
影响因子：
20.3
通讯作者：
Murphy, William J.
中科院分区：
文献类型：
--
作者：
Sungur, Can M.;Tang-Feldman, Yajarayma J.;Murphy, William J.
自然杀伤（NK）细胞表达抑制性受体，对特定的主要组织相容性复合体I类（MHC-I）单倍型具有不同的结合亲和力。NK细胞可分别基于其结合MHC-I的能力或不结合MHC-I的能力分类为许可的或未许可的。异基因造血干细胞移植（allo-HSCT）后供体与宿主MHC在其发育中的作用尚不清楚。在相互的MHC不同的同种异体移植和从头NK细胞恢复期间，根据供体MHC-I单倍型的许可模式确定的许可和非许可的NK细胞群体的耗竭导致对鼠巨细胞病毒（MCMV）感染的易感性显著增加。在供体MHC-I的情况下，许可的Ly 49 H（+）NK细胞的相应扩增发生在这些细胞比未许可的NK细胞产生更大的干扰素γ。因此，NK对MCMV的许可行为对应于小鼠中allo-HSCT后的供体而非受体MHC单倍型。
Natural killer (NK) cells express inhibitory receptors with varied binding affinities to specific major histocompatibility complex class I (MHC-I) haplotypes. NK cells can be classified as licensed or unlicensed based on their ability or inability to bind MHC-I, respectively. The role of donor vs host MHC on their development after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is not known. Following reciprocal MHC-disparate allogeneic transplants and during de novo NK-cell recovery, depletion of the licensed and not unlicensed population of NK cells as determined by the licensing patterns of donor MHC-I haplotypes, resulted in significantly increased susceptibility to murine cytomegalovirus (MCMV) infection. A corresponding expansion of the licensed Ly49H(+) NK cells occurred with greater interferon gamma production by these cells than unlicensed NK cells in the context of donor MHC-I. Thus, NK licensing behavior to MCMV corresponds to the donor, and not recipient, MHC haplotype after allo-HSCT in mice.