Immunological control of a murine gammaherpesvirus independent of CD8+ T cells.
Immunological control of a murine gammaherpesvirus independent of CD8+ T cells.
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鼠伽马疱疹病毒的免疫控制不依赖于 CD8 T 细胞。
DOI：
10.1099/0022-1317-80-2-477
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Doherty,PC
中科院分区：
文献类型：
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作者：
Stevenson,PG;Cardin,RD;Christensen,JP;Doherty,PC
在用鼠伽马疱疹病毒-68进行呼吸道攻击之前或之后，通过MAb治疗成年胸腺切除的C57 BL/6J小鼠的T细胞亚群。当 CD4+ 或 CD8+ T 细胞群大大减少时，针对急性感染的保护作用得以维持，而同时去除这两种 T 细胞亚群则被证明总是致命的。同样的消耗对已经感染的小鼠几乎没有影响。结果首先表明CD4+和CD8+T细胞在处理急性感染中发挥重要作用，其次病毒特异性抗体有助于控制这种伽马疱疹病毒的持续感染。
Adult thymectomized C57 BL/6J mice were depleted of T cell subsets by MAb treatment either prior to, or after, respiratory challenge with murine gammaherpesvirus-68. Protection against acute infection was maintained when either the CD4+ or the CD8+ T cell population was greatly diminished, whereas the concurrent removal of both T cell subsets proved invariably fatal. The same depletions had little effect on mice with established infection. The results indicate firstly that both CD4+ and CD8+ T cells play a significant part in dealing with the acute infection, and secondly that virus-specific antibody contributes to controlling persistent infection with this gammaherpesvirus.