SARS-CoV-2 reinfections during the Delta and Omicron waves.
SARS-CoV-2 reinfections during the Delta and Omicron waves.
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DOI：
10.1172/jci.insight.162007
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发表时间：
2022-10-24
期刊：
影响因子：
8
通讯作者：
Mostafa, Heba H.
中科院分区：
文献类型：
--
作者：
Morris, C. Paul;Eldesouki, Raghda E.;Fall, Amary;Gaston, David C.;Norton, Julie M.;Gallagher, Nicholas D.;Luo, Chun Huai;Abdullah, Omar;Klein, Eili Y.;Mostafa, Heba H.
最近有报告称，SARS-CoV-2再感染率增加，一些地区的再感染是基于首次感染后至少90天的第二次阳性PCR检测。在这项研究中，我们使用约翰霍普金斯SARS-CoV-2基因组监测数据来评估2020年3月至2022年7月期间测序验证、确认和推断的再感染频率。在我们的系统中有2次或2次以上SARS-CoV-2检测阳性的患者，作为我们监测工作的一部分，被确定为我们研究的队列。比较患者最初和后来样本的SARS-CoV-2基因组。共有755名患者（920份样本）在初次检测后至少90天内检测结果呈阳性，两次检测之间的中位时间为377天。对231个样品进行了测序，并在127个样品中成功。测序成功率在Omicron激增期间飙升;与测序失败的病例相比，这些病例中首次感染的中位天数更高。共有122名（98%）患者显示出再感染的证据;其中45名患者有序列验证的再感染，77名患者有推断的再感染（后来的测序显示，患者最初感染时没有循环的进化枝）。在45例经序列验证的再感染患者中，43例（96%）有Omicron变异引起的再感染，41例（91%）有症状，32例（71%）在第二次感染前接种疫苗，6例（13%）免疫抑制，仅2例（4%）住院。序列验证的再感染随着Omicron激增而增加，但通常与轻度感染相关。资金由约翰霍普金斯流感研究和监测卓越中心（HHSN 272201400007 C）、CDC（75 D30121 C11061）、约翰霍普金斯大学校长基金研究响应、约翰霍普金斯病理学系和马里兰州卫生部提供。
Increased SARS-CoV-2 reinfection rates have been reported recently, with some locations basing reinfection on a second positive PCR test at least 90 days after initial infection. In this study, we used Johns Hopkins SARS-CoV-2 genomic surveillance data to evaluate the frequency of sequencing-validated, confirmed, and inferred reinfections between March 2020 and July 2022. Patients who had 2 or more positive SARS-CoV-2 tests in our system, with samples sequenced as a part of our surveillance efforts, were identified as the cohort for our study. SARS-CoV-2 genomes of patients’ initial and later samples were compared. A total of 755 patients (920 samples) had a positive test at least 90 days after the initial test, with a median time between tests of 377 days. Sequencing was attempted on 231 samples and was successful in 127. Rates of successful sequencing spiked during the Omicron surge; there was a higher median number of days from initial infection in these cases compared with those with failed sequences. A total of 122 (98%) patients showed evidence of reinfection; 45 of these patients had sequence-validated reinfection and 77 had inferred reinfections (later sequencing showed a clade that was not circulating when the patient was initially infected). Of the 45 patients with sequence-validated reinfections, 43 (96%) had reinfections that were caused by the Omicron variant, 41 (91%) were symptomatic, 32 (71%) were vaccinated prior to the second infection, 6 (13%) were immunosuppressed, and only 2 (4%) were hospitalized. Sequence-validated reinfections increased with the Omicron surge but were generally associated with mild infections. Funding was provided by the Johns Hopkins Center of Excellence in Influenza Research and Surveillance (HHSN272201400007C), CDC (75D30121C11061), Johns Hopkins University President’s Fund Research Response, Johns Hopkins Department of Pathology, and the Maryland Department of Health.
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影响因子：
4
作者：
Falahi S;Kenarkoohi A
通讯作者：
Kenarkoohi A
影响因子：
9.4
作者：
Mostafa HH;Carroll KC;Hicken R;Berry GJ;Manji R;Smith E;Rakeman JL;Fowler RC;Leelawong M;Butler-Wu SM;Quintero D;Umali-Wilcox M;Kwiatkowski RW;Persing DH;Weir F;Loeffelholz MJ
通讯作者：
Loeffelholz MJ
影响因子：
5.7
作者：
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影响因子：
8.8
作者：
Uhteg, Katharine;Jarrett, Junko;Mostafa, Heba H.
通讯作者：
Mostafa, Heba H.
影响因子：
9.4
作者：
Hogan, Catherine A.;Garamani, Natasha;Pinsky, Benjamin A.
通讯作者：
Pinsky, Benjamin A.