Sleep Problem Risk for Adolescents With Sickle Cell Disease: Sociodemographic, Physical, and Disease-related Correlates.
Sleep Problem Risk for Adolescents With Sickle Cell Disease: Sociodemographic, Physical, and Disease-related Correlates.
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患有镰状细胞病的青少年的睡眠问题风险：社会人口学、身体和疾病相关的相关性。
DOI：
10.1097/mph.0000000000001067
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Fuh,BengR
中科院分区：
文献类型：
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作者：
Valrie,CeceliaR;Trout,KrystalL;Bond,KayzandraE;Ladd,RebeccaJ;Huber,NichelleL;Alston,KristenJ;Sufrinko,AliciaM;Everhart,Erik;Fuh,BengR
本研究的目的是调查在青春期，SCD是否会在社会人口学因素（即种族和性别）的影响之外增加睡眠不良的风险，并探讨社会人口学、身体（即年龄和青春期状态）和疾病相关因素（即SCD基因型和使用羟基脲）与青春期睡眠问题风险之间的关系。黑人青少年（年龄，12至17岁）与SCD（n= 53）从区域儿科SCD诊所在东南部和健康的黑人青少年（n= 160）的样本从初中和高中招募。回归分析表明，SCD是唯一相关的睡眠更多，睡眠质量差以上的社会人口因素的影响。具有更严重的SCD基因型与睡眠质量差有关，而更高的青春期状态与一周内睡眠时间更长有关。研究结果表明，需要对睡眠问题进行系统评估，更多地关注基因型更严重和青春期状态更高的青少年。未来的研究应该集中在描述这一人群睡眠问题的轨迹，确定关键的风险因素，并阐明将风险因素与睡眠问题风险联系起来的机制，以帮助为这一人群量身定制干预措施。
The aims of the current study were to investigate whether SCD incurs an additional risk for poor sleep over and above the influence of sociodemographic factors (ie, race and sex) during adolescence, and to explore the relationships between sociodemographic, physical (ie, age and pubertal status), and disease-related factors (ie, SCD genotype and hydroxyurea use) on sleep problem risk during adolescence. Black adolescents (age, 12 to 17 y) with SCD (n= 53) were recruited from regional pediatric SCD clinics in the southeast and a sample of healthy black adolescents (n= 160) were recruited from middle and high schools. Regression analyses indicated that SCD was uniquely related to sleeping more, and worse sleep quality over and above the influence of sociodemographic factors. Having a more severe SCD genotype was related to worse sleep quality and higher pubertal status was related to sleeping longer during the week. Results indicate the need for systematic assessments of sleep problems, with more a focus on youth with more severe genotypes and higher pubertal status. Future research should focus on characterizing trajectories of sleep problems in this population, identifying key risk factors, and elucidating mechanisms linking risk factors to sleep problem risk to aid in tailoring interventions for this population.