PROSTHETIC VALVE ENDOCARDITIS CAUSED BY BRUCELLA-MELITENSIS - A REPORT OF 4 CASES SUCCESSFULLY TREATED WITH TETRACYCLINE, STREPTOMYCIN, AND SULFAMETHOXAZOLE AND TRIMETHOPRIM PLUS VALVE-REPLACEMENT
PROSTHETIC VALVE ENDOCARDITIS CAUSED BY BRUCELLA-MELITENSIS - A REPORT OF 4 CASES SUCCESSFULLY TREATED WITH TETRACYCLINE, STREPTOMYCIN, AND SULFAMETHOXAZOLE AND TRIMETHOPRIM PLUS VALVE-REPLACEMENT
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DOI：
10.1001/archinte.147.6.1141
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发表时间：
1987-06-01
影响因子：
--
通讯作者：
DERABAGO, G
中科院分区：
文献类型：
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作者：
FERNANDEZGUERRERO, ML;MARTINELL, J;DERABAGO, G
Optimal treatment of prosthetic valve endocarditis due to Brucella melitensis is unknown. The presence of ring abscess makes extensive surgical debridement and valve replacement essential steps of management. Antimicrobial therapy with tetracycline hydrochloride plus streptomycin sulfate or sulfamethoxazole and trimethoprim can achieve the sterilization of infected cardiac tissue. Late bland periprosthetic leaks occur frequently. Reoperation can be safely performed after a period of antimicrobial therapy. Prolonged treatment with doxycycline hyclate seems advisable.
