Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family.
Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family.
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DOI：
10.1084/jem.186.7.1165
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发表时间：
1997-10-06
期刊：
影响因子：
--
通讯作者：
Smith CA
中科院分区：
文献类型：
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作者：
Degli-Esposti MA;Smolak PJ;Walczak H;Waugh J;Huang CP;DuBose RF;Goodwin RG;Smith CA
TRAIL-R3, a new member of the TRAIL receptor family, has been cloned and characterized. TRAIL-R3 encodes a 299 amino acid protein with 58 and 54% overall identity to TRAIL-R1 and -R2, respectively. Transient expression and quantitative binding studies show TRAIL-R3 to be a plasma membrane–bound protein capable of high affinity interaction with the TRAIL ligand. The TRAIL-R3 gene maps to human chromosome 8p22-21, clustered with the genes encoding two other TRAIL receptors. In contrast to TRAIL-R1 and -R2, this receptor shows restricted expression, with transcripts detectable only in peripheral blood lymphocytes and spleen. The structure of TRAIL-R3 is unique when compared to the other TRAIL receptors in that it lacks a cytoplasmic domain and appears to be glycosyl-phosphatidylinositol–linked. Moreover, unlike TRAIL-R1 and -R2, in a transient overexpression system TRAIL-R3 does not induce apoptosis.
