Adherence to plant-based dietary pattern and risk of breast cancer among Iranian women
Adherence to plant-based dietary pattern and risk of breast cancer among Iranian women
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DOI：
10.1038/s41430-021-00869-7
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发表时间：
2021-04-07
影响因子：
4.7
通讯作者：
Zendehdel, Kazem
中科院分区：
文献类型：
--
作者：
Sasanfar, Bahareh;Toorang, Fatemeh;Zendehdel, Kazem
以前的研究评估了植物性饮食与乳腺癌风险之间的联系，而不是健康和不健康的植物性饮食。这项研究调查了伊朗妇女以植物为基础的饮食模式与乳腺癌风险之间的关系。方法对412例乳腺癌患者和456例健康对照者进行以医院为基础的病例对照研究。饮食数据的收集使用一个有效的和可靠的168项FFQ。我们创建了三种模式，包括整体植物性饮食指数（PDI），健康植物性饮食指数（hPDI）和不健康植物性饮食指数（uPDI）。在PDI、hPDI和uPDI的四分位数之间比较乳腺癌的风险。结果我们没有发现坚持PDI和uPDI评分与女性乳腺癌发病率之间存在显著相关性。然而，在粗模型中，hPDI评分越高与乳腺癌风险呈负相关（OR：0.63; 95%CI：0.43-0.93，P = 0.01）。调整年龄和精力后，我们发现乳腺癌风险与较高的hPDI评分之间存在更强的相关性（OR：0.55; 95%CI：0.37-0.82，P = 0.002）。在按绝经状态分层后，我们没有发现PDI和uPDI评分与乳腺癌风险之间存在显著相关性。然而，绝经前和绝经后的妇女在最高的四分之一的hPDI评分比那些在最低的四分之一有较低的乳腺癌的风险。结论：我们发现在整个研究人群中hPDI与乳腺癌的几率呈负相关。在按绝经状态分层后，这种相关性在绝经前和绝经后妇女中也可见。
Objectives Previous studies assessed the link between plant based diet and breast cancer risk rather than healthy and unhealthy plant based diet. This study examined the relation between plant-based dietary pattern and risk of breast cancer among Iranian women. Methods This hospital-based case-control study was conducted among 412 women with pathologically confirmed breast cancer within the past year and 456 apparently healthy controls. Dietary data were collected using a validated and reliable 168-item FFQ. We created three patterns including overall plant-based diet index (PDI), a healthful plant-based diet index (hPDI), and an unhealthful plant-based diet index (uPDI). The risk of breast cancer was compared across quartiles of PDI, hPDI, and uPDI. Results we did not find significant association between adherence to PDI and uPDI score and odds of breast cancer among women. However, a greater score of hPDI was inversely associated to the risk of breast cancer (OR: 0.63; 95% CI: 0.43-0.93, P = 0.01), in the crude model. After adjustment for age and energy, we saw stronger association between breast cancer risk and higher hPDI score (OR: 0.55; 95% CI: 0.37-0.82, P = 0.002). After stratified by menopausal status, we did not find significant association between PDI and uPDI score and risk of breast cancer. However, pre- and postmenopausal women in the highest quartile of hPDI score had lower risk of breast cancer than those in the lowest quartile. Conclusions we found an inverse significant association between hPDI and odds of breast cancer in the whole population of study. After stratifying by menopausal status, this correlation was also seen both in pre and postmenopausal women.