Preclinical evidence of Alzheimer changes in progressive mild cognitive impairment: a qualitative and quantitative SPECT study
Preclinical evidence of Alzheimer changes in progressive mild cognitive impairment: a qualitative and quantitative SPECT study
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DOI：
10.1111/j.1600-0404.2006.00661.x
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发表时间：
2006-08-01
影响因子：
3.5
通讯作者：
Katayama, Y.
中科院分区：
文献类型：
--
作者：
Ishiwata, A.;Sakayori, O.;Katayama, Y.
目的：脑单光子发射计算机断层扫描（SPECT）基线水平可预测有进展为进展性轻度认知障碍（PMCI）风险的轻度认知障碍（MCI）患者。方法：28名受试者[12名MCI患者、6名可能患有阿尔茨海默病（AD）的患者以及10名正常受试者]接受了脑SPECT基线检查，并进行了平均36个月的临床随访。结果：在12名MCI患者中，6名进展为PMCI，6名保持稳定。基线SPECT显示，在6名PMCI患者中的5名患者中，海马旁回（-5%）、顶叶外侧（-8%）和后扣带回（-11%）皮质存在不对称灌注减少，这种减少与轻度AD患者一致。与PMCI相比，可能患有AD的患者额叶皮质灌注减少尤为显著（P < 0.05）。结论：基线SPECT能够识别MCI患者中进展为PMCI的脑灌注异常。这种成像方式可能有助于MCI治疗的分层。
Objectives: Baseline brain single-photon emission computed tomography (SPECT) can predict mild cognitive impairment (MCI) patients at risk for progressive MCI (PMCI). Methods: Twenty-eight subjects [12 MCI, 6 with probable Alzheimer's Disease (AD), and 10 normal subjects] underwent baseline brain SPECT and were clinically followed for a mean period of 36 months. Results: Of 12 MCI patients, 6 progressed to PMCI and 6 remained stable. Baseline SPECT identified asymmetric perfusion reduction in the parahippocampus (-5%), lateral parietal (-8%), and posterior cingulate (-11%) cortices - reductions consistent with that of mild AD - in five of the six PMCI patients. Significant perfusion reduction was observed particularly in the frontal cortices of probable AD when compared with PMCI (P < 0.05). Conclusion: Baseline SPECT can identify brain perfusion abnormalities among patients with MCI for progression to PMCI. This imaging modality may aid in MCI treatment stratification.