Clinical Features of Children Hospitalized with Malaria-A Study from Bikaner, Northwest India
Clinical Features of Children Hospitalized with Malaria-A Study from Bikaner, Northwest India
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DOI：
10.4269/ajtmh.2010.09-0633
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发表时间：
2010-11-01
影响因子：
3.3
通讯作者：
Das, Ashish
中科院分区：
文献类型：
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作者：
Kochar, Dhanpat Kumar;Tanwar, Gajanand Singh;Das, Ashish
印度西北部比卡纳尔地区报告成人重症间日疟，但儿童疟疾报道较少。本文对303例住院儿童疟疾进行前瞻性研究，经外周血涂片和快速诊断试验确诊为重度间日疟，用聚合酶链式反应(PCR)进一步证实恶性疟、间日疟和混合(恶性疟+间日疟)混合感染的比例分别为61.01%、33.99%和4.95%。49.5%(150/303)的儿童疟疾有严重疾病。与恶性疟原虫单独感染(427%[79/185])或混合感染(40%[6/15]，OR=257[95%CI=0.88~7.48])相比，间日疟单感染的危险性最大(63.1%[65/103])，优势比[OR]=2.3[95%可信区间=1.40-3.76]P=0.0001
Severe Plasmodium vivax malaria in adults has been reported from Bikaner (northwestern India) but the reports on children are scanty This prospective study was done on 303 admitted children of malaria The diagnosis was done by peripheral blood smear and rapid diagnostic test Further confirmation of severe P vivax monoinfection was done by polymerase chain reaction (PCR) The proportion of P falciparum, P vivax, and mixed (P falciparum and P vivax) infection was 61 01%, 33 99%, and 4 95%, respectively Severe disease was present in 49 5% (150/303) children with malaria, with the risk greatest among P vivax monoinfection (63 1% [65/103]) compared with P falciparum, either alone (427% [79/185], odds ratio [OR] = 2 3 [95% confidence interval (CI) = 1 40-3 76] P = 0 001) or mixed infections (40% [6/15], OR = 257 [95% CI = 0 88-7 48]) In children