XV. Malignant lymphoma as a consequence of clonal evolution.
XV. Malignant lymphoma as a consequence of clonal evolution.
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DOI：
10.1002/hon.2073
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发表时间：
2013-06-01
影响因子：
3.3
通讯作者：
Seto, Masao
中科院分区：
文献类型：
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作者：
Seto, Masao
自从免疫球蛋白(IG)和T细胞受体基因分别作为克隆标记物被引入以来，B细胞和T细胞恶性肿瘤被认为是一种单克隆性疾病。特征性的染色体易位与特定的疾病实体相关，并已知在淋巴瘤的发展中发挥关键作用。然而，众所周知，仅有染色体易位并不足以产生肿瘤。因此，额外的基因组改变被认为在淋巴增生症中起着重要作用。自从阵列比较基因组杂交(阵列CGH)技术问世以来，对拷贝数变化进行了分析，发现每种疾病亚型都有一种特有的变化模式[1]。现在的研究重点是这些基因改变如何参与淋巴瘤的发展和/或临床病理特征的表现。在我们的分析过程中，我们发现来自同一原始克隆的肿瘤内克隆异质性。我们将讨论恶性淋巴瘤发生发展过程中克隆进化引起的克隆异质性的生物学意义。
B-cell and T-cell malignancies have been identified as a monoclonal disease since the introduction of Immunoglobulin (IG) and T-cell receptor genes as clonal markers, respectively. Characteristic chromosome translocations are associated with specific disease entities and are known to play a pivotal role in lymphoma development. It is well known, however, that chromosome translocation alone is not sufficient to produce tumours. Additional genomic alterations have therefore been thought to play important roles in lymphomagenesis. Since the advent of array comparative genomic hybridization (array CGH) technology, copy number alterations have been analysed and it was discovered that each disease subtype has a characteristic alteration pattern [1]. Investigation now focuses on how these genetic alterations participate in lymphoma development and/or manifestation of clinicopathological features. During the course of our analyses, we found that there is intra-tumour clonal heterogeneity derived from the same original clone. The biological significance of clonal heterogeneity caused by clonal evolution during the development of malignant lymphoma will be discussed.