Urinary cadmium levels during pregnancy and postpartum - A longitudinal study
Urinary cadmium levels during pregnancy and postpartum - A longitudinal study
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DOI：
10.1007/bf02784556
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发表时间：
1996-06-01
影响因子：
3.9
通讯作者：
Llobet, JM
中科院分区：
文献类型：
--
作者：
Hernandez, M;Schuhmacher, M;Llobet, JM
众所周知，怀孕会引起生理、代谢和荷尔蒙的变化。因此，微量金属的代谢可能会受到影响。本研究的目的是评估孕期和产后妇女的尿镉水平。这项调查是在一组来自西班牙加泰罗尼亚南部(NE)的非职业性接触镉的女性中进行的。分别于孕前、孕6、10、26、30周及产后5、24周采集尿样。采用石墨炉原子吸收光谱法测定尿镉含量。同时测定血浆中锌和铜的浓度。此外，为了评估孕期饮食的效果，还测定了锌、铁和钙的饮食摄入量。在妊娠的最后两个三个月中，血浆锌水平显著下降，而血浆铜浓度在同一时期显著升高。尿镉浓度范围为0.05~3.79微克/克肌酐(几何平均值为0.49+/-2.26微克/克肌酐)。孕期和产后尿镉浓度未见明显变化。
It is well established that pregnancy induces physiological, metabolical and hormonal changes. As a consequence, trace metal metabolism can be affected. The aim of the present study was to assess the urinary cadmium levels in women during gestation and postpartum. The survey was conducted in a group of nonoccupationally cadmium-exposed women from Southern Catalonia (NE, Spain). Urine samples were obtained before pregnancy, during the 6th, 10th, 26th, and 30th wk of gestation, as well as during the 5th and 24th wk after delivery. Urinary cadmium levels were determined by graphite furnace atomic absorption spectrophotometry. The concentrations of zinc and copper in plasma were also measured. Moreover, to assess the effect of the diet during pregnancy, dietary ingestions of zinc, iron, and calcium were also determined. A significant decrease of plasma zinc levels could be observed during the last two trimesters of pregnancy, while plasma copper concentrations significantly increased during the same period. Urinary cadmium concentrations ranged from 0.05 to 3.79 mu g/g creatinine (geometric mean 0.49+/-2.26 mu g/g creatinine). No significant changes in urinary cadmium concentrations during pregnancy and postpartum could be observed.