ABO-Incompatible Living Donor Kidney Transplantation in a Human Immunodeficiency Virus-Positive Recipient From a Human Immunodeficiency Virus-Positive Donor: A Case Report
ABO-Incompatible Living Donor Kidney Transplantation in a Human Immunodeficiency Virus-Positive Recipient From a Human Immunodeficiency Virus-Positive Donor: A Case Report
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DOI：
10.1016/j.transproceed.2020.07.008
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发表时间：
2020-11-01
影响因子：
0.9
通讯作者：
Brockmann, Jens
中科院分区：
文献类型：
--
作者：
Katou, Shadi;Vogel, Thomas;Brockmann, Jens
人类免疫缺陷病毒（HIV）感染不再是实体器官移植的绝对禁忌症，但由于普遍的保留意见和医疗困难，这种情况仍然具有挑战性，并且很少探索。我们描述了一位51岁的多囊肾病终末期肾功能衰竭的男性患者，他接受了abo血型不相容的49岁男性伴侣的肾移植。术后早期发现疑似急性排斥反应，经类固醇脉冲治疗成功。在根据肾功能调整抗逆转录病毒药物后，供体和受体的病毒载量都无法检测到。据我们所知，这是首例hiv阳性供体与hiv阳性受体之间abo血型不相容活体肾移植成功的报道，该病例似乎是一种有价值的方法，具有良好的结果。
A human immunodeficiency virus (HIV) infection is no longer an absolute contraindication for solid organ transplantation, yet such a setting is still challenging and little explored because of general reservations and medical difficulties. We describe a 51-year-old man with end-stage renal failure due to polycystic kidney disease who underwent an ABO-incompatible kidney transplantation from his 49-year-old male partner. Early postoperative course revealed an episode of suspected acute rejection, which was successfully managed with a steroid pulse. Both donor and recipient continued to have an undetectable viral load after adjusting antiretroviral medication to renal function. To the best of our knowledge, this is the first report of a successful ABO-incompatible living donor kidney transplantation from an HIV-positive donor in an HIV-positive recipient, and this case seems to be a valuable approach with favorable results.