Transcriptional regulation of heart valve progenitor cells.
Transcriptional regulation of heart valve progenitor cells.
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DOI：
10.1007/s00246-009-9616-x
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发表时间：
2010-04
影响因子：
1.6
通讯作者：
Yutzey, Katherine E.
中科院分区：
文献类型：
--
作者：
Chakraborty, Santanu;Combs, Michelle D.;Yutzey, Katherine E.
心脏瓣膜的发育和正常功能需要信号分子、转录因子和结构蛋白之间复杂的相互作用，这些相互作用在时间和空间上受到严格的调控。在这里，我们审查的作用，所需的正常瓣膜发育的特定方面的关键转录因子。心脏瓣膜的早期祖细胞位于内膜垫中，其表达间充质的特征性转录因子，包括Twist 1、Tbx 20、Msx 1和Msx 2。随着瓣叶成熟，它们由复杂的分层细胞外基质蛋白组成，这些蛋白由NFATc1、Sox 9和Scleraxis的转录功能调节。这些因子中的每一个在相关结缔组织谱系的分化中具有类似的功能。总之，特定转录因子的精确定时和局部功能控制正常瓣膜结构和功能所必需的细胞增殖、分化、伸长和重塑过程。此外，越来越多的证据表明，这些相同的转录因子有助于先天性以及退行性瓣膜疾病。
The development and normal function of the heart valves requires complex interactions among signaling molecules, transcription factors and structural proteins that are tightly regulated in time and space. Here we review the roles of critical transcription factors that are required for specific aspects of normal valve development. The early progenitors of the heart valves are localized in endocardial cushions that express transcription factors characteristic of mesenchyme, including Twist1, Tbx20, Msx1 and Msx2. As the valve leaflets mature, they are composed of complex stratified extracellular matrix proteins that are regulated by the transcriptional functions of NFATc1, Sox9, and Scleraxis. Each of these factors has analogous functions in differentiation of related connective tissue lineages. Together, the precise timing and localized functions of specific transcription factors control cell proliferation, differentiation, elongation, and remodeling processes that are necessary for normal valve structure and function. In addition, there is increasing evidence that these same transcription factors contribute to congenital, as well as degenerative, valve disease.
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DOI：
10.1387/ijdb.082747rb
发表时间：
2009
期刊：
The International journal of developmental biology
影响因子：
--
作者：
Barnes RM;Firulli AB
通讯作者：
Firulli AB
影响因子：
10.5
作者：
Akiyama, H;Chaboissier, MC;de Crombrugghe, B
通讯作者：
de Crombrugghe, B
影响因子：
20.1
作者：
Combs MD;Yutzey KE
通讯作者：
Yutzey KE
影响因子：
64.8
作者：
Garg, V;Muth, AN;Srivastava, D
通讯作者：
Srivastava, D
影响因子：
2.7
作者：
Chimal-Monroy, J;Rodriguez-Leon, J;Hurle, JM
通讯作者：
Hurle, JM