A multimodal language region in the ventral visual pathway
A multimodal language region in the ventral visual pathway
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DOI：
10.1038/28389
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发表时间：
1998-07-16
期刊：
影响因子：
64.8
通讯作者：
Friston, K
中科院分区：
文献类型：
--
作者：
Büchel, C;Price, C;Friston, K
阅读单词和命名图片涉及视觉刺激与语音和语义知识的关联。左侧基底后颞叶（BA 37）位于视觉皮层和更前颞叶皮层之间，该区域的脑损伤导致阅读和命名缺陷（1，2）。暗示该区域参与语言处理的其他证据来自正常受试者（3-7）和发育性阅读障碍受试者（8，9）的阅读功能神经成像研究。在这里，我们测试是否阅读的视觉组件是必不可少的激活BA 37通过比较皮质激活引起的文字处理先天失明，晚盲和视力正常的科目使用功能性神经成像。尽管使用不同的方式（视觉和触觉），所有受试者组显示了一个共同的激活BA 37的字相对于非字字母串。这些发现与BA 37是一个整合了来自许多地区的融合输入的关联区域的提议一致（10）。我们的研究证实了依赖于会聚区的大脑功能理论的预测;一个输入（即视觉）的缺失不会改变这样一个会聚区的响应特性。
Reading words and naming pictures involves the association of visual stimuli with phonological and semantic knowledge. Damage to a region of the brain in the left basal posterior temporal lobe (BA37), which is strategically situated between the visual cortex and the more anterior temporal cortex, leads to reading and naming deficits(1,2). Additional evidence implicating this region in linguistic processing comes from functional neuroimaging studies of reading in normal subjects(3-7) and subjects with developmental dyslexia(8,9). Here we test whether the visual component of reading is essential for activation of BA37 by comparing cortical activations elicited by word processing in congenitally blind, late-blind and sighted subjects using functional neuroimaging. Despite the different modalities used (visual and tactile), all groups of subjects showed a common activation of BA37 by words relative to non-word letter-strings. These findings agree with the proposal that BA37 is an association area that integrates converging inputs from many regions(10). Our study confirms a prediction of theories of brain function that depend on convergence zones; the absence of one input (that is, visual) does not alter the response properties of such a convergence region.