Induction of Colonic M Cells during Intestinal Inflammation
Induction of Colonic M Cells during Intestinal Inflammation
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DOI：
10.1016/j.ajpath.2015.12.015
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发表时间：
2016-05-01
影响因子：
6
通讯作者：
Lo, David D.
中科院分区：
文献类型：
--
作者：
Bennett, Kaila M.;Parnell, Erinn A.;Lo, David D.
肠M（微折叠）细胞是覆盖小肠中淋巴组织的特化上皮细胞。与常见的肠上皮细胞不同，M细胞缺乏有组织的顶端刷状缘，并且能够将微粒穿过粘膜屏障转运到下面的抗原呈递细胞。我们发现，在葡聚糖硫酸钠和枸橼酸啮齿动物模型的结肠炎，显着增加的派尔集合淋巴结（PP）表型M细胞的数量诱导在结肠上皮炎症的高峰，往往伴随着松散的组织固有层浸润。PP型M细胞被认为依赖于细胞因子，包括肿瘤坏死因子（TNF）-α和核因子κ-B配体的受体激活剂;这些细胞因子也被发现在炎症组织中被诱导。M细胞的诱导被抗TNF-α阻断剂消除，这表明抗TNF-α治疗在临床环境中可能具有类似的作用，尽管功能后果尚不清楚。我们的研究结果表明，炎性精氨酸诱导的PP型M细胞可能是一个有用的相关慢性肠道炎症。
Intestinal M (microfold) cells are specialized epithelial cells overlying lymphoid tissues in the small intestine. Unlike common enterocytes, M cells lack an organized apical brush border, and are able to transcytose microparticles across the mucosal barrier to underlying antigen-presenting cells. We found that in both the dextran sodium sulfate and Citrobacterrodentium models of colitis, significantly increased numbers of Peyer's patch (PP) phenotype M cells were induced at the peak of inflammation in colonic epithelium, often accompanied by loosely organized lamina propria infiltrates. PP type M cells are thought to be dependent on cytokines, including tumor necrosis factor (TNF)-alpha and receptor activator of nuclear factor kappa-B ligand; these cytokines were also found to be induced in the inflamed tissues. The induction of M cells was abrogated by anti-TNF-alpha blockade, suggesting that anti-TNF-alpha therapies may have similar effects in clinical settings, although the functional consequences are not clear. Our results suggest that inflammatory cytokine-induced PP type M cells may be a useful correlate of chronic intestinal inflammation.