The molecular pathology of sarcomas
The molecular pathology of sarcomas
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DOI：
10.3233/cbm-2011-0170
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发表时间：
2011-01-01
影响因子：
3.1
通讯作者：
Lazar, Alexander J.
中科院分区：
文献类型：
--
作者：
Powers, Martin;Zhang, Wei;Lazar, Alexander J.
肉瘤是一种罕见的间叶性恶性肿瘤，有100多种特异性类型和许多良性的潜在拟态。原位和前驱病变通常没有描述，因此该领域的分子病理学主要集中在分子诊断、预后和治疗靶点的确定上。本章讨论了分子方法的应用，提供深入了解肉瘤的发病机制，以及目前应用于或可能很快影响这种复杂的肿瘤阵列的临床管理的分子方法。
Sarcomas are rare malignancies of mesenchymal lineage with more than 100 specific types and many benign potential mimics. In situ and precursor lesions are generally not described and thus much of molecular pathology in this field concentrates on molecular diagnosis, prognosis and determination of therapeutic targets. This chapter discusses the applications of molecular methodologies that provide insight into pathogenesis of sarcoma, and of molecular methods which are currently applied to, or will likely soon influence, the clinical management of this complex array of tumors.