Adherence, compliance, and HAART.
Adherence, compliance, and HAART.
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依从性、依从性和 HAART。
DOI：
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发表时间：
1997
期刊：
影响因子：
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通讯作者：
Gerald Friedland
中科院分区：
文献类型：
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作者：
RN Ann Williams;Gerald Friedland
开发和使用新的高效抗逆转录病毒疗法（HAART）需要讨论这些方案成功的关键因素，即，患者依从性。术语依从性更常用，但坚持是首选术语，被认为更准确，因为它意味着并承认患者在治疗中的选择。为了获得对病毒复制的持久抑制，必须近乎完美地遵守剂量、时间、频率和食物要求。初级保健医生必须善于帮助病人坚持他们的方案。决定患者依从性的因素包括：1）患者特征，2）临床医生特征，3）临床医生-患者关系，4）疾病特征，5）治疗方案特征。确定依从性的各种方法包括患者自我报告、药丸计数、药房记录的审查、药物测定和替代标记物的确定。药物事件监测系统记录打开药瓶的频率和时间。必须制定以患者为中心的策略，如教育和参与治疗决策，以支持和提高依从性;行为疗法也可能有用。临床医生还必须利用继续教育来学习帮助他们的病人。在可能的情况下，应尽可能简化治疗方案，临床医生必须与患者保持良好的关系。
The development and use of new, highly active antiretroviral therapy (HAART) requires a discussion of a factor that is key to the success of these regimens, i.e., patient adherence. The term compliance is more often used, but adherence is the preferred term and considered more accurate because it implies and recognizes patient choice in therapy. To gain a durable suppression of viral replication, near-perfect adherence to dosage, timing, frequency, and food requirements is necessary. Primary care physicians must be skilled in helping patients adhere to their regimens. Factors determining patient adherence include the following: 1) patient characteristics, 2) clinician characteristics, 3) clinician-patient relationship, 4) characteristic of the illness, and 5) characteristics of the regimen. Various methods of determining adherence include patient self-reports, pill counts, review of pharmacy records, drug assays, and determination of surrogate markers. The medication-event monitoring system records frequency and time of opening pill bottles. Patient-focused strategies, such as education and involvement in treatment decision making, must be developed to support and improve adherence; behavior therapy may also be useful. Clinicians must also utilize continuing education to learn to assist their patients. When possible, regimens should be simplified as much as possible, and clinicians must maintain a good relationship with their patients.