Human ferritins present in the sera of nude mice transplanted with human neuroblastoma or hepatocellular carcinoma.
Human ferritins present in the sera of nude mice transplanted with human neuroblastoma or hepatocellular carcinoma.
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DOI：
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发表时间：
1984-09
期刊：
影响因子：
11.2
通讯作者：
H. Hann;M. Stahlhut;I. Millman
中科院分区：
文献类型：
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作者：
H. Hann;M. Stahlhut;I. Millman
15只裸鼠接种人神经母细胞瘤细胞系，14只接种人原发性肝细胞癌细胞系。在患肿瘤的小鼠血清中检测到人铁蛋白。在14只携带人神经母细胞瘤的小鼠中，12只血清中含有人肝型铁蛋白（8至52 ng/ml），其中3只还含有HeLa型铁蛋白（酸性铁蛋白）（29至40 ng/ml）。在10只荷人原发性肝细胞癌的裸鼠中，8只具有人肝型铁蛋白（10至820 ng/ml），其中1只具有43 ng/ml水平的HeLa型铁蛋白。由于这些小鼠血清中的铁蛋白是由人类肿瘤细胞产生的，这些观察结果支持了这样的假设，即癌症患者血清中经常发现的铁蛋白升高部分来自他们的肿瘤。
Fifteen nude mice were inoculated with a human neuroblastoma cell line and 14 with a human primary hepatocellular carcinoma cell line. Human ferritins were detected in the sera of the mice which developed tumors. Of 14 mice bearing human neuroblastoma, 12 had human liver-type ferritin (8 to 52 ng/ml) in their sera, and three of these also had HeLa-type ferritin (acidic ferritin) (29 to 40 ng/ml). Of 10 nude mice bearing human primary hepatocellular carcinoma, eight had human liver-type ferritin (10 to 820 ng/ml), and one of these had HeLa-type ferritin at a level of 43 ng/ml. Since the ferritins in the sera of these mice were produced by the human tumor cells, these observations support the hypothesis that the elevated ferritins often found in the serum of patients with cancer are, in part, derived from their tumors.