Thyrotropin and thyroglobulin as an index of optimal iodine intake: Correlation with iodine excretion of 39,913 euthyroid patients
Thyrotropin and thyroglobulin as an index of optimal iodine intake: Correlation with iodine excretion of 39,913 euthyroid patients
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DOI：
10.1089/thy.1997.7.593
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发表时间：
1997-08-01
期刊：
影响因子：
6.6
通讯作者：
Eber, O
中科院分区：
文献类型：
--
作者：
Buchinger, W;LorenzWawschinek, O;Eber, O
青少年和成人的膳食碘摄入量建议为每天150微克。促甲状腺素（TSH）和甲状腺球蛋白（Tg）可作为评估碘缺乏病的监测指标。我们使用改良的二砷酸盐方法比较了 2311 名未经治疗的甲状腺功能正常患者的 TSH 和 Tg、游离三碘甲状腺原氨酸和甲状腺素血清水平与尿碘排泄之间的关系。当 TSH 和 Tg 值处于正常范围的下限时，可以假定碘摄入量充足。根据尿碘排泄量和甲状腺肿大小对患者进行分组。在碘排泄量为每克肌酐201至300微克碘的组中，TSH值最低，甚至Tg水平也较低。我们得出的结论是，每天大约 250 微克的碘摄入量与对甲状腺细胞的最低 TSH 刺激有关。根据甲状腺大小分组，长期缺碘的单结节性和多结节性甲状腺肿患者的Tg水平显着升高，而实际尿碘排泄量没有显着差异。此外，还对1984年至1996年间39,913名甲状腺功能正常患者的碘排泄量进行了检查。奥地利于 1963 年通过法律引入碘盐（10 mg KI/kg），并于 1990 年增加至 20 mg KI/kg 盐。直到 1993 年，碘排泄量最初增加，随后在 1994 年和 1995 年减少，1996 年没有进一步变化。这些结果表明，自 1984 年以来，碘摄入量有所改善；然而，1996年，三分之一的调查患者的碘排泄量低于每克肌酐100微克，超过80%的患者的碘排泄量低于每克肌酐200微克。
The recommendations for the dietary allowance of iodine are 150 mu g per day for adolescents and adults. Thyrotropin (TSH) and thyroglobulin (Tg) can be used as surveillance indicators for assessing iodine deficiency disorders. We compared the relation between TSH and Tg, free triiodothyronine, and thyroxine serum levels with urinary iodine excretion in 2311 untreated euthyroid patients using our modified cericarsenite method. An adequate iodine intake may be assumed when TSH and Tg values are at the lower end of the normal range. Patients were grouped according to urinary iodine excretion and goiter size. In the group with an iodine excretion between 201 and 300 mu g of iodine per gram of creatinine, the lowest TSH values and even low Tg levels could be shown. We conclude that an iodine intake of approximately 250 mu g/day is associated with the lowest TSH stimulation to thyrocytes. In the groups separated according to thyroid size, significantly higher Tg levels were found in the patients with uninodular and multinodular goiter as a result of longstanding iodine deficiency, whereas actual urinary iodine excretion did not differ significantly.Additionally, iodine excretion of 39,913 euthyroid patients between 1984 and 1996 was examined. In Austria iodized salt (10 mg KI/kg) was introduced by law in 1963 and increased to 20 mg KI/kg salt in 1990. An initial increase of iodine excretion until 1993 was followed by a decrease in 1994 and 1995 without further changes in 1996.These results show that iodine intake has improved since 1984; however, in 1996 iodine excretion in one-third of the investigated patients was under 100 mu g per gram of creatinine and more than 80% had less than 200 mu g per gram of creatinine.