Neural circuitry for stimulus selection in the zebrafish visual system
Neural circuitry for stimulus selection in the zebrafish visual system
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DOI：
10.1016/j.neuron.2020.12.002
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发表时间：
2021-03-03
期刊：
影响因子：
16.2
通讯作者：
Baier, Herwig
中科院分区：
文献类型：
--
作者：
Fernandes, Antonio M.;Mearns, Duncan S.;Baier, Herwig
当在环境中导航时，动物需要优先考虑对最相关刺激的反应。虽然存在选择性视觉注意的理论框架，但其电路实现仍然模糊。在这里，我们研究了斑马鱼幼虫如何选择同时呈现的视觉刺激。我们发现，赢家通吃（WTA）和平均策略的混合最能模拟行为反应。我们确定了两个电路的活动模式预测竞争的视觉对象的相对显着性。仅呈现给一只眼睛的刺激通过内层视网膜中的WTA计算来选择。另一方面，双眼呈现的刺激是通过峡部核（NI）和顶盖之间的双向、双侧连接来处理的。这种半球间的计算导致WTA或平均反应。NI神经元的光遗传刺激和激光消融会破坏刺激选择和行为动作选择。因此，视竞争刺激的相对位置而定，视网膜顶盖和峡部顶盖回路的组合使选择性视觉注意成为可能。
When navigating the environment, animals need to prioritize responses to the most relevant stimuli. Although a theoretical framework for selective visual attention exists, its circuit implementation has remained obscure. Here we investigated how larval zebrafish select between simultaneously presented visual stimuli. We found that a mix of winner-take-all (WTA) and averaging strategies best simulates behavioral responses. We identified two circuits whose activity patterns predict the relative saliencies of competing visual objects. Stimuli presented to only one eye are selected by WTA computation in the inner retina. Binocularly presented stimuli, on the other hand, are processed by reciprocal, bilateral connections between the nucleus isthmi (NI) and the tectum. This interhemispheric computation leads to WTA or averaging responses. Optogenetic stimulation and laser ablation of NI neurons disrupt stimulus selection and behavioral action selection. Thus, depending on the relative locations of competing stimuli, a combination of retinotectal and isthmotectal circuits enables selective visual attention.